Record No:1
| ACCESS NO | D100229 |
| GENE_NAME | KLF4 |
| DESCRIPTION | Kruppel-like factor 4 |
| ALIASES | EZF, GKLF. |
| NCBI_ENTREZ_NO | 9314 |
| UNIPROT_ACCESS_NO | O43474 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma and effect of house dust mite allergens on human airway epithelial cell. |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | This is an transcription factor significantly up regulated in asthma. |
| REFERENCE | 17919147 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity ( sequence-specific DNA binding), proximal promoter sequence-specific DNA binding, transcription factor activity ( sequence-specific DNA binding transcription factor recruiting), transcriptional activator activity ( RNA polymerase II proximal promoter sequence-specific DNA binding), RNA polymerase II transcription factor binding, transcriptional activator activity ( RNA polymerase II transcription factor binding), transcription cofactor binding, nucleic acid binding, DNA binding, double-stranded DNA binding, DNA binding transcription factor activity, protein binding, beta-catenin binding, transcription factor binding, zinc ion binding, phosphatidylinositol 3-kinase regulator activity, histone deacetylase binding, sequence-specific DNA binding, ranscription regulatory region DNA binding, metal ion binding, promoter-specific chromatin binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, mesodermal cell fate determination, negative regulation of cell proliferation, epidermal cell differentiation, response to organic substance, positive regulation of gene expression, negative regulation of gene expression, negative regulation of phosphatidylinositol 3-kinase signaling, negative regulation of muscle hyperplasia, negative regulation of angiogenesis, stem cell population maintenance, cell differentiation, negative regulation of cell migration, post-embryonic camera-type eye development, negative regulation of NF-kappaB transcription factor activity, positive regulation of cellular protein metabolic process, response to retinoic acid, negative regulation of heterotypic cell-cell adhesion, somatic stem cell population maintenance, post-embryonic hemopoiesis, regulation of cell proliferation, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of DNA binding transcription factor activity, regulation of phosphatidylinositol 3-kinase activity, negative regulation of interleukin-8 biosynthetic process, positive regulation of nitric oxide biosynthetic process, fat cell differentiation, regulation of cell differentiation, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of hemoglobin biosynthetic process, negative regulation of smooth muscle cell proliferation, regulation of axon regeneration, epidermis morphogenesis, negative regulation of inflammatory response, positive regulation of protein metabolic process, negative regulation of protein kinase B signaling, positive regulation of telomerase activity, canonical Wnt signaling pathway, negative regulation of response to cytokine stimulus, pri-miRNA transcription by RNA polymerase II, cellular response to hydrogen peroxide, negative regulation of ERK1 and ERK2 cascade, cellular response to retinoic acid, cellular response to growth factor stimulus, cellular response to organic cyclic compound, cellular response to cycloheximide, cellular response to laminar fluid shear stress, negative regulation of cell migration involved in sprouting angiogenesis, cellular response to peptide, positive regulation of sprouting angiogenesis, positive regulation of core promoter binding, negative regulation of leukocyte adhesion to arterial endothelial cell, cellular response to leukemia inhibitory factor, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of chemokine (C-X-C motif) ligand 2 production. |
| BIOGRID_INTERACTION_ID | 114726 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200437 |
| MONOCLONAL_ANTIBODY | Anti-KLF4 antibody for Human. |