Record No:1
| ACCESS NO | D100885 |
| GENE_NAME | CCL2 |
| DESCRIPTION | C-C motif chemokine ligand 2 |
| ALIASES | GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF. |
| NCBI_ENTREZ_NO | 6347 |
| UNIPROT_ACCESS_NO | P13500 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Rhinitis |
| SAMPLE | Nasal Mucosa |
| TECHNIQUES | cDNA Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Recruits regulatory and effector CD4+ and CD8+ T cells. Was upregulated in Allergic Rhinitis. |
| REFERENCE | 17982926 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protein kinase activity, signaling receptor binding, cytokine activity, protein binding, chemokine activity, CCR2 chemokine receptor binding, CCR chemokine receptor binding. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, angiogenesis, monocyte chemotaxis, protein phosphorylation, chemotaxis, inflammatory response, immune response, humoral immune response, cytoskeleton organization, cell adhesion, signal transduction, cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway ( coupled to cyclic nucleotide second messenger), JAK-STAT cascade, regulation of cell shape, response to bacterium, animal organ morphogenesis, regulation of signaling receptor activity, viral genome replication, cytokine-mediated signaling pathway, cellular homeostasis, neutrophil chemotaxis, lipopolysaccharide-mediated signaling pathway, negative regulation of glial cell apoptotic process, helper T cell extravasation, PERK-mediated unfolded protein response, protein kinase B signaling, negative regulation of neuron apoptotic process, positive regulation of GTPase activity, astrocyte cell migration, cellular response to fibroblast growth factor stimulus, eosinophil chemotaxis, macrophage chemotaxis, lymphocyte chemotaxis, positive regulation of T cell activation, positive regulation of nitric-oxide synthase biosynthetic process, cell chemotaxis, chemokine-mediated signaling pathway, positive regulation of ERK1 and ERK2 cascade, cellular response to lipopolysaccharide, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, cellular response to organic cyclic compound, positive regulation of calcium ion import, negative regulation of vascular endothelial cell proliferation, negative regulation of G1/S transition of mitotic cell cycle, positive regulation of endothelial cell apoptotic process, positive regulation of apoptotic cell clearance, negative regulation of natural killer cell chemotaxis. |
| BIOGRID_INTERACTION_ID | 112251 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200922 200923 200924 200925 |
| MONOCLONAL_ANTIBODY | Anti-MCP1 antibody for Mouse, Human, Rat. |