Record No:1
| ACCESS NO | D101539 |
| GENE_NAME | STAT6 |
| DESCRIPTION | Signal transducer and activator of transcription 6 |
| ALIASES | D12S1644, IL-4-STATB, STAT6C. |
| NCBI_ENTREZ_NO | 6778 |
| UNIPROT_ACCESS_NO | P42226 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Asthma. |
| SAMPLE | CD4 T cells and CD161 T cells |
| TECHNIQUES | FACS |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Phospho-STAT6 was increased in asthmatic subjects. |
| REFERENCE | 17919711 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity ( sequence-specific DNA binding), transcriptional activator activity ( RNA polymerase II transcription regulatory region sequence-specific DNA binding), DNA binding, DNA binding transcription factor activity, obsolete signal transducer activity, protein binding, protein phosphatase binding, identical protein binding, sequence-specific DNA binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, T-helper 1 cell lineage commitment, negative regulation of type 2 immune response, DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, signal transduction, cytokine-mediated signaling pathway, positive regulation of type I interferon production, mammary gland epithelial cell proliferation, response to cytokine, interleukin-4-mediated signaling pathway, regulation of cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of isotype switching to IgE isotypes, mammary gland morphogenesis, cellular response to hydrogen peroxide, cellular response to reactive nitrogen species. |
| BIOGRID_INTERACTION_ID | 112655 |
| SNP_ID | 300413 300414 300987 300992 300993 301000 301109 301184 300761 |
| DRUG_ID | - |
| STRUCTURE_ID | 201834 201835 201836 |
| MONOCLONAL_ANTIBODY | Anti-STAT6 antibody for Mouse, Human, Rat; Anti-STAT6 (phospho Y641) antibody for Human. |