Record No:1
| ACCESS NO | D102014 |
| GENE_NAME | MYLK |
| DESCRIPTION | Myosin light chain kinase |
| ALIASES | AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP0831, smMLCK. |
| NCBI_ENTREZ_NO | 4638 |
| UNIPROT_ACCESS_NO | Q15746 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma and Allergic Rhinitis |
| SAMPLE | Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE51392 |
| COMMENTS | Downregulated in the lower airways in patients with allergic rhinitis and allergic asthma. |
| REFERENCE | 24475887 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Actin binding, protein kinase activity, protein serine/threonine kinase activity, myosin light chain kinase activity, protein binding, calmodulin binding, ATP binding, kinase activity, transferase activity, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Protein phosphorylation, muscle contraction, smooth muscle contraction, tonic smooth muscle contraction, phosphorylation, positive regulation of cell migration, bleb assembly, positive regulation of calcium ion transport, aorta smooth muscle tissue morphogenesis, cellular hypotonic response, positive regulation of wound healing. |
| BIOGRID_INTERACTION_ID | 110722 |
| SNP_ID | 300962 300963 300964 |
| DRUG_ID | - |
| STRUCTURE_ID | 201392 201393 |
| MONOCLONAL_ANTIBODY | Anti-Myosin light chain kinase/MLCK antibody for Mouse, Rat, Human. |