Record No:1
| ACCESS NO | D102016 |
| GENE_NAME | DUSP1 |
| DESCRIPTION | Dual specificity phosphatase 1 |
| ALIASES | CL100, HVH1, MKP-1, MKP1, PTPN10. |
| NCBI_ENTREZ_NO | 1843 |
| UNIPROT_ACCESS_NO | P28562 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic rhinitis and Asthma |
| SAMPLE | Primary Nasal Epithelial Cells and Primary Bronchial Epithelial Cells |
| TECHNIQUES | Microarray and real time PCR |
| OMICS | Genomics |
| STUDY | High Throughput and Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE44037 |
| COMMENTS | Dowregulated in upper airways(data in suplimentary table). |
| REFERENCE | 24282527 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding, protein tyrosine/serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity, hydrolase activity, phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, growth factor binding. |
| GO_BIOLOGICAL_PROCESS | Inactivation of MAPK activity, endoderm formation, protein dephosphorylation, response to oxidative stress, cell cycle, response to light stimulus, response to organic substance, dephosphorylation, response to estradiol, response to retinoic acid, cellular response to hormone stimulus, response to testosterone, peptidyl-tyrosine dephosphorylation, intracellular signal transduction, peptidyl-threonine dephosphorylation, response to hydrogen peroxide, regulation of apoptotic process, positive regulation of apoptotic process, negative regulation of apoptotic process, negative regulation of MAP kinase activity, negative regulation of MAPK cascade, response to glucocorticoid, negative regulation of meiotic cell cycle, response to cAMP, response to calcium ion, negative regulation of ERK1 and ERK2 cascade, mitotic cell cycle arrest, regulation of mitotic cell cycle spindle assembly checkpoint, negative regulation of DNA biosynthetic process. |
| BIOGRID_INTERACTION_ID | 108176 |
| SNP_ID | 300840 300957 300841 |
| DRUG_ID | - |
| STRUCTURE_ID | 201854 201855 201856 201857 |
| MONOCLONAL_ANTIBODY | Anti-MKP-1 antibody for Human. |