Record No:1
| ACCESS NO | D102109 |
| GENE_NAME | ID2 |
| DESCRIPTION | Inhibitor of DNA binding 2 |
| ALIASES | GIG8A, ID2H, bHLHb26. |
| NCBI_ENTREZ_NO | 3398 |
| UNIPROT_ACCESS_NO | Q02363 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE14908 |
| COMMENTS | Upregulated in asthma. Involved in Th2/IgE regulation. |
| REFERENCE | 19414752 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II transcription factor activity ( sequence-specific DNA binding), RNA polymerase II transcription factor binding, transcriptional repressor activity ( RNA polymerase II transcription factor binding), DNA binding transcription factor activity, protein binding, transcription factor binding, ion channel binding, protein dimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, metanephros development, natural killer cell differentiation, thigmotaxis, leukocyte differentiation, membranous septum morphogenesis, bundle of His development, DNA-templated transcription, regulation of DNA-templated transcription, multicellular organism development, heart development, circadian rhythm, adult locomotory behavior, entrainment of circadian clock, positive regulation of gene expression, negative regulation of gene expression, oligodendrocyte development, regulation of lipid metabolic process, olfactory bulb development, neuron differentiation, circadian regulation of gene expression, mammary gland epithelial cell proliferation, regulation of circadian rhythm, entrainment of circadian clock by photoperiod, enucleate erythrocyte differentiation, negative regulation of DNA binding, negative regulation of DNA binding transcription factor activity, locomotor rhythm, negative regulation of B cell differentiation, positive regulation of fat cell differentiation, positive regulation of erythrocyte differentiation, positive regulation of macrophage differentiation, negative regulation of neuron differentiation, negative regulation of osteoblast differentiation, positive regulation of blood pressure, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, cell development, cell maturation, rhythmic process, Peyers patch development, embryonic digestive tract morphogenesis, positive regulation of smooth muscle cell proliferation, neuron fate commitment, cell morphogenesis involved in neuron differentiation, positive regulation of astrocyte differentiation, negative regulation of oligodendrocyte differentiation, regulation of cell cycle, adipose tissue development, mammary gland alveolus development, epithelial cell differentiation involved in mammary gland alveolus development, endodermal digestive tract morphogenesis, positive regulation of cell cycle arrest, cellular response to lithium ion, positive regulation of transcription involved in G1/S transition of mitotic cell cycle, cellular senescence, regulation of G1/S transition of mitotic cell cycle, negative regulation of neural precursor cell proliferation. |
| BIOGRID_INTERACTION_ID | 109624 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 202638 |
| MONOCLONAL_ANTIBODY | Anti-ID2 antibody for Human. |