Record No:1
| ACCESS NO | D102115 |
| GENE_NAME | FOXP3 |
| DESCRIPTION | Forkhead box P3 |
| ALIASES | AIID, DIETER, IPEX, JM2, PIDX, XPID. |
| NCBI_ENTREZ_NO | 50943 |
| UNIPROT_ACCESS_NO | Q9BZS1 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | Microarray and real time PCR |
| OMICS | Genomics |
| STUDY | High Throughput and Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE14908 |
| COMMENTS | Elevated in atopic asthma. Helps in mediating Treg suppresive function. |
| REFERENCE | 19414752 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II transcription factor activity ( sequence-specific DNA binding), core promoter binding, nucleic acid binding, DNA binding, DNA binding transcription factor activity, transcription factor activity ( RNA polymerase II distal enhancer sequence-specific binding), transcription corepressor activity, protein binding, histone acetyltransferase binding, protein homodimerization activity, histone deacetylase binding, sequence-specific DNA binding, metal ion binding, NF-kappaB binding, NFAT protein binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, B cell homeostasis, cytokine production, myeloid cell homeostasis, CD4-positive and CD25-positive ( alpha-beta regulatory) T cell differentiation, CD4-positive and CD25-positive ( alpha-beta regulatory) T cell lineage commitment, T cell mediated immunity, tolerance induction, tolerance induction to self antigen, regulation of immunoglobulin production, positive regulation of T cell tolerance induction, regulation of T cell anergy, positive regulation of T cell anergy, negative regulation of chronic inflammatory response, negative regulation of T cell cytokine production, positive regulation of peripheral T cell tolerance induction, chromatin remodeling, DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, negative regulation of cell proliferation, response to virus, anatomical structure morphogenesis, positive regulation of gene expression, negative regulation of gene expression, regulation of Wnt signaling pathway, cell differentiation, negative regulation of histone deacetylation, negative regulation of NF-kappaB transcription factor activity, negative regulation of interferon-gamma production, negative regulation of interleukin-10 production, negative regulation of interleukin-17 production, negative regulation of interleukin-2 production, negative regulation of interleukin-4 production, negative regulation of interleukin-5 production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, positive regulation of interleukin-4 production, negative regulation of CREB transcription factor activity, positive regulation of CD4-positive and CD25-positive ( alpha-beta regulatory) T cell differentiation, positive regulation of transforming growth factor beta1 production, positive regulation of immature T cell proliferation in thymus, positive regulation of histone acetylation, negative regulation of histone acetylation, negative regulation of cytokine biosynthetic process, T cell activation, negative regulation of T cell proliferation, T cell homeostasis, negative regulation of DNA binding transcription factor activity, regulatory T cell differentiation, negative regulation of interferon-gamma biosynthetic process, negative regulation of interleukin-2 biosynthetic process, regulation of regulatory T cell differentiation, positive regulation of regulatory T cell differentiation, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of activated T cell proliferation, negative regulation of isotype switching to IgE isotypes, regulation of isotype switching to IgG isotypes, negative regulation of lymphocyte proliferation, negative regulation of cytokine secretion, negative regulation of inflammatory response, negative regulation of immune response, T cell receptor signaling pathway, negative regulation of T-helper 17 cell differentiation. |
| BIOGRID_INTERACTION_ID | 119170 |
| SNP_ID | 300002 300893 300894 300916 300895 300896 300897 300003 |
| DRUG_ID | - |
| STRUCTURE_ID | 201191 201192 |
| MONOCLONAL_ANTIBODY | Anti-FOXP3 antibody for Human, Cynomolgus monkey, Rhesus monkey, Rat, Mouse, Monkey. |