Record No:1
| ACCESS NO | D102119 |
| GENE_NAME | TIAM1 |
| DESCRIPTION | T cell lymphoma invasion and metastasis 1 |
| ALIASES | TIAM-1. |
| NCBI_ENTREZ_NO | 7074 |
| UNIPROT_ACCESS_NO | Q13009 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | Microarray and real time PCR |
| OMICS | Genomics |
| STUDY | High Throughput and Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE14908 |
| COMMENTS | Upregulated in atopic asthma. Involved in Treg expression and function. |
| REFERENCE | 19414752 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Obsolete signal transducer activity ( downstream of receptor), guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, protein binding, microtubule binding, lipid binding, Ras GTPase binding, kinase binding, Rac guanyl-nucleotide exchange factor activity, receptor tyrosine kinase binding, Rac GTPase binding. |
| GO_BIOLOGICAL_PROCESS | Cardiac muscle hypertrophy, apoptotic process, cell-matrix adhesion, signal transduction, G-protein coupled receptor signaling pathway, positive regulation of cell proliferation, regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition, positive regulation of neuron projection development, cell migration, Rac protein signal transduction, positive regulation of cell migration, positive regulation of protein binding, regulation of Rho protein signal transduction, intracellular signal transduction, response to cocaine, positive regulation of apoptotic process, positive regulation of JUN kinase activity, ephrin receptor signaling pathway, positive regulation of axonogenesis, regulation of small GTPase mediated signal transduction, Wnt signaling pathway ( planar cell polarity pathway), positive regulation of dendritic spine morphogenesis, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of ERK1 and ERK2 cascade, protein localization to membrane, activation of GTPase activity, NMDA selective glutamate receptor signaling pathway, positive regulation of Schwann cell chemotaxis, regulation of dopaminergic neuron differentiation, regulation of modification of postsynaptic actin cytoskeleton, neuron projection extension, regulation of non-canonical Wnt signaling pathway. |
| BIOGRID_INTERACTION_ID | 112930 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 202649 202650 |
| MONOCLONAL_ANTIBODY | - |