Record No:1
| ACCESS NO | D102412 |
| GENE_NAME | CCL5 |
| DESCRIPTION | C-C motif chemokine ligand 5 |
| ALIASES | D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP. |
| NCBI_ENTREZ_NO | 6352 |
| UNIPROT_ACCESS_NO | P13501 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis |
| SAMPLE | Skin Biopsies |
| TECHNIQUES | mRNA array, qRT-PCR, Immunofluorescence Staining |
| OMICS | Genomics, Others |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | CCL5 mRNA expression is significantly increased in both lesional and non lesional skin of Atopic Dermatitis patients as compared to healthy skin. CCL5 protein is highly expressed in Atopic Dermatitis skin. |
| REFERENCE | 22445417 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Phosphatidylinositol phospholipase C activity, protein kinase activity, cytokine activity, protein binding, chemokine activity, phospholipase activator activity, receptor signaling protein tyrosine kinase activator activity, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding, chemoattractant activity, chemokine receptor binding, identical protein binding, protein homodimerization activity, protein self-association, chemokine receptor antagonist activity, CCR chemokine receptor binding. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, dendritic cell chemotaxis, monocyte chemotaxis, regulation of chronic inflammatory response, calcium ion transport, cellular calcium ion homeostasis, exocytosis, chemotaxis, inflammatory response, immune response, leukocyte cell-cell adhesion, G-protein coupled receptor signaling pathway, cell-cell signaling, response to virus, response to toxic substance, regulation of signaling receptor activity, positive regulation of activation of Janus kinase activity, positive regulation of macrophage chemotaxis, positive regulation of T cell chemotaxis, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of smooth muscle cell migration, cytokine-mediated signaling pathway, positive regulation of cell migration, neutrophil chemotaxis, positive regulation of cellular biosynthetic process, activation of phospholipase D activity, lipopolysaccharide-mediated signaling pathway, positive regulation of cell-cell adhesion mediated by integrin, response to cytokine, positive regulation of homotypic cell-cell adhesion, response to tumor necrosis factor, positive regulation of T cell proliferation, neutrophil activation, positive regulation of phosphorylation, positive regulation of tyrosine phosphorylation of STAT protein, protein kinase B signaling, positive regulation of GTPase activity, negative regulation by host of viral transcription, cellular response to fibroblast growth factor stimulus, positive regulation of viral genome replication, negative regulation of viral genome replication, positive regulation of innate immune response, negative regulation of G-protein coupled receptor protein signaling pathway, positive regulation of cell adhesion, positive regulation of translational initiation, positive regulation of JAK-STAT cascade, eosinophil chemotaxis, macrophage chemotaxis, lymphocyte chemotaxis, positive regulation of smooth muscle cell proliferation, positive regulation of epithelial cell proliferation, regulation of insulin secretion, regulation of T cell activation, positive chemotaxis, protein tetramerization, positive regulation of calcium ion transport, cell chemotaxis, positive regulation of protein tyrosine kinase activity, chemokine-mediated signaling pathway, negative regulation of chemokine-mediated signaling pathway, negative regulation of T cell apoptotic process, positive regulation of T cell apoptotic process, positive regulation of ERK1 and ERK2 cascade, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, cellular response to organic cyclic compound, positive regulation of monocyte chemotaxis, regulation of neuron death, negative regulation of macrophage apoptotic process, positive regulation of T cell migration, positive regulation of natural killer cell chemotaxis. |
| BIOGRID_INTERACTION_ID | 112255 |
| SNP_ID | 300914 300928 300929 300930 300915 |
| DRUG_ID | - |
| STRUCTURE_ID | 201491 201492 201493 201494 201495 201496 201497 201498 201499 |
| MONOCLONAL_ANTIBODY | Anti-RANTES antibody for Human, Mouse. |