Record No:1


ACCESS NOD102876
GENE_NAMEIL6R
DESCRIPTIONInterleukin 6 receptor
ALIASESCD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80.
NCBI_ENTREZ_NO3570
UNIPROT_ACCESS_NOP08887
ORGANISMHuman
DISEASE_PHENOTYPEAsthma
SAMPLEBronchial Epithelial Cells (BEC), Broncho Alveolar Lavage (BAL) Cells
TECHNIQUESMicroarray
OMICSGenomics
STUDYHigh Throughput
GEO_PRIDE_ACCESS_NOGSE67940, GSE43696
COMMENTSThe expression levels of IL6R were consistently higher in asthma or severe asthma than controls or mild/moderate asthma in cells from BAL.
REFERENCE27050946
IMMUNITY_TERMYes
GO_MOLECULAR_FUNCTIONCytokine receptor activity, contributes to ciliary neurotrophic factor receptor activity, contributes to interleukin-6 receptor activity, contributes to interleukin-6 receptor binding, interleukin-12 receptor binding, protein binding, growth factor activity, enzyme binding, cytokine binding, interleukin-6 binding, interleukin-12 alpha subunit binding, protein homodimerization activity, interleukin-23 receptor binding, ciliary neurotrophic factor binding.
GO_BIOLOGICAL_PROCESSHepatic immune response, monocyte chemotaxis, positive regulation of leukocyte chemotaxis, positive regulation of T-helper 1 type immune response, acute-phase response, positive regulation of cell proliferation, regulation of signaling receptor activity, positive regulation of activation of Janus kinase activity, cytokine-mediated signaling pathway, endocrine pancreas development, positive regulation of chemokine production, positive regulation of interferon-gamma production, positive regulation of interleukin-6 production, positive regulation of natural killer cell activation, response to cytokine, positive regulation of activated T cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of osteoblast differentiation, positive regulation of smooth muscle cell proliferation, positive regulation of lymphocyte proliferation, positive regulation of peptidyl-tyrosine phosphorylation, defense response to Gram-negative bacterium, positive regulation of NK T cell activation, interleukin-6-mediated signaling pathway, ciliary neurotrophic factor-mediated signaling pathway, positive regulation of glomerular mesangial cell proliferation, extrinsic apoptotic signaling pathway.
BIOGRID_INTERACTION_ID109784
SNP_ID300020
300452
301001
301002
301003
300453
DRUG_ID4041
4208
STRUCTURE_ID203756
203757
MONOCLONAL_ANTIBODYAnti-IL-6R antibody for Human, Mouse.