Record No:1
ACCESS NO | D102876 |
GENE_NAME | IL6R |
DESCRIPTION | Interleukin 6 receptor |
ALIASES | CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80. |
NCBI_ENTREZ_NO | 3570 |
UNIPROT_ACCESS_NO | P08887 |
ORGANISM | Human |
DISEASE_PHENOTYPE | Asthma |
SAMPLE | Bronchial Epithelial Cells (BEC), Broncho Alveolar Lavage (BAL) Cells |
TECHNIQUES | Microarray |
OMICS | Genomics |
STUDY | High Throughput |
GEO_PRIDE_ACCESS_NO | GSE67940, GSE43696 |
COMMENTS | The expression levels of IL6R were consistently higher in asthma or severe asthma than controls or mild/moderate asthma in cells from BAL. |
REFERENCE | 27050946 |
IMMUNITY_TERM | Yes |
GO_MOLECULAR_FUNCTION | Cytokine receptor activity, contributes to ciliary neurotrophic factor receptor activity, contributes to interleukin-6 receptor activity, contributes to interleukin-6 receptor binding, interleukin-12 receptor binding, protein binding, growth factor activity, enzyme binding, cytokine binding, interleukin-6 binding, interleukin-12 alpha subunit binding, protein homodimerization activity, interleukin-23 receptor binding, ciliary neurotrophic factor binding. |
GO_BIOLOGICAL_PROCESS | Hepatic immune response, monocyte chemotaxis, positive regulation of leukocyte chemotaxis, positive regulation of T-helper 1 type immune response, acute-phase response, positive regulation of cell proliferation, regulation of signaling receptor activity, positive regulation of activation of Janus kinase activity, cytokine-mediated signaling pathway, endocrine pancreas development, positive regulation of chemokine production, positive regulation of interferon-gamma production, positive regulation of interleukin-6 production, positive regulation of natural killer cell activation, response to cytokine, positive regulation of activated T cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of osteoblast differentiation, positive regulation of smooth muscle cell proliferation, positive regulation of lymphocyte proliferation, positive regulation of peptidyl-tyrosine phosphorylation, defense response to Gram-negative bacterium, positive regulation of NK T cell activation, interleukin-6-mediated signaling pathway, ciliary neurotrophic factor-mediated signaling pathway, positive regulation of glomerular mesangial cell proliferation, extrinsic apoptotic signaling pathway. |
BIOGRID_INTERACTION_ID | 109784 |
SNP_ID | 300020 300452 301001 301002 301003 300453 |
DRUG_ID | 4041 4208 |
STRUCTURE_ID | 203756 203757 |
MONOCLONAL_ANTIBODY | Anti-IL-6R antibody for Human, Mouse. |