Record No:1
| ACCESS NO | D103318 |
| GENE_NAME | miR-17 |
| DESCRIPTION | MicroRNA 17 |
| ALIASES | MIR17-5p, MIR91, MIRN17, MIRN91, hsa-mir-17, miR-17, miR17-3p, miRNA17, miRNA91, MIR17. |
| NCBI_ENTREZ_NO | 406952 |
| UNIPROT_ACCESS_NO | - |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | Microarray, qRT-PCR |
| OMICS | Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Compared with healthy controls, miR-17 was down regulated in CD4 T cells of Asthma patients. microRNA-17 regulates Treg/Th17 ratio of CD4 T cells in asthma patients by downregulating RORĪ³T. |
| REFERENCE | 30594051 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | mRNA binding involved in posttranscriptional gene silencing. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of systemic arterial blood pressure, outflow tract morphogenesis, negative regulation of gene expression, positive regulation of cardiac muscle cell apoptotic process, negative regulation of low-density lipoprotein particle clearance, negative regulation of toll-like receptor signaling pathway, gene silencing by miRNA, miRNA mediated inhibition of translation, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of blood pressure, positive regulation of fibroblast proliferation, positive regulation of phagocytosis, cellular response to lipopolysaccharide, cellular response to hypoxia, positive regulation of cytokine production involved in inflammatory response, positive regulation of hydrogen peroxide-mediated programmed cell death, negative regulation of mitochondrial membrane permeability involved in apoptotic process, negative regulation of hydrogen peroxide-induced cell death, positive regulation of cardiac muscle hypertrophy in response to stress, negative regulation of sprouting angiogenesis, positive regulation of connective tissue replacement involved in inflammatory response wound healing, positive regulation of metalloendopeptidase activity, positive regulation of vascular smooth muscle cell proliferation, negative regulation of apoptosome assembly, positive regulation of pulmonary blood vessel remodeling, positive regulation of smooth muscle hypertrophy, negative regulation of vascular associated smooth muscle cell apoptotic process, negative regulation of receptor-mediated endocytosis involved in cholesterol transport, negative regulation of cellular senescence, negative regulation of intrinsic apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 135801 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | - |
| MONOCLONAL_ANTIBODY | - |