Record No:1
| ACCESS NO | D103344 |
| GENE_NAME | BMP2 |
| DESCRIPTION | Bone morphogenetic protein 2 |
| ALIASES | BDA2, BMP2A, SSFSC. |
| NCBI_ENTREZ_NO | 650 |
| UNIPROT_ACCESS_NO | P12643 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Asthma |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE18965 |
| COMMENTS | BMP2 was up regulated in atopic asthmatics as compared to healthy control. |
| REFERENCE | 25515564 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Retinol dehydrogenase activity, signaling receptor binding, cytokine activity, transforming growth factor beta receptor binding, protein binding, growth factor activity, phosphatase activator activity, co-receptor binding, SMAD binding, protein heterodimerization activity, BMP receptor binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, activation of MAPK activity, skeletal system development, ossification, osteoblast differentiation, branching involved in ureteric bud morphogenesis, response to hypoxia, in utero embryonic development, epithelial to mesenchymal transition, positive regulation of protein phosphorylation, positive regulation of endothelial cell proliferation, chondrocyte differentiation, BMP signaling pathway involved in heart induction, atrioventricular valve morphogenesis, endocardial cushion morphogenesis, negative regulation of Wnt signaling pathway involved in heart development, proteoglycan metabolic process, regulation of DNA-templated transcription, protein phosphorylation, inflammatory response, Notch signaling pathway, cell-cell signaling, multicellular organism development, heart development, negative regulation of cell proliferation, response to bacterium, animal organ morphogenesis, regulation of signaling receptor activity, positive regulation of gene expression, negative regulation of gene expression, positive regulation of epithelial to mesenchymal transition, positive regulation of pathway-restricted SMAD protein phosphorylation, negative regulation of steroid biosynthetic process, positive regulation of phosphatase activity, telencephalon development, telencephalon regionalization, cell differentiation, positive regulation of Wnt signaling pathway, bone mineralization, positive regulation of cell migration, positive regulation of bone mineralization, BMP signaling pathway, protein destabilization, positive regulation of protein binding, negative regulation of aldosterone biosynthetic process, positive regulation of osteoblast proliferation, cardiocyte differentiation, embryonic heart tube anterior/posterior pattern specification, bone mineralization involved in bone maturation, odontogenesis of dentin-containing tooth, positive regulation of odontogenesis, regulation of odontogenesis of dentin-containing tooth, regulation of apoptotic process, positive regulation of apoptotic process, regulation of MAPK cascade, positive regulation of MAPK cascade, negative regulation of insulin-like growth factor receptor signaling pathway, cell fate commitment, positive regulation of cell differentiation, positive regulation of fat cell differentiation, positive regulation of neuron differentiation, positive regulation of osteoblast differentiation, positive regulation of ossification, negative regulation of cell cycle, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, cell development, positive regulation of astrocyte differentiation, mesenchymal cell differentiation, inner ear development, negative regulation of calcium-independent cell-cell adhesion, cartilage development, cardiac muscle cell differentiation, cardiac muscle tissue morphogenesis, oxidation-reduction process, pericardium development, corticotropin hormone secreting cell differentiation, thyroid-stimulating hormone-secreting cell differentiation, cardiac epithelial to mesenchymal transition, pathway-restricted SMAD protein phosphorylation, SMAD protein signal transduction, mesenchyme development, positive regulation of Wnt signaling pathway by BMP signaling pathway, positive regulation of cartilage development, positive regulation of ERK1 and ERK2 cascade, cellular response to growth factor stimulus, cellular response to organic cyclic compound, cellular response to BMP stimulus, mesenchymal cell proliferation involved in ureteric bud development, negative regulation of canonical Wnt signaling pathway, positive regulation of p38MAPK cascade, positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus, positive regulation of pri-miRNA transcription by RNA polymerase II, negative regulation of cortisol biosynthetic process, negative regulation of cardiac muscle cell differentiation. |
| BIOGRID_INTERACTION_ID | 107118 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204034 |
| MONOCLONAL_ANTIBODY | Anti-BMP2 antibody for Mouse, Rat, Rabbit, Human. |