Record No:1
| ACCESS NO | D103347 |
| GENE_NAME | TGFBR1 |
| DESCRIPTION | Transforming growth factor beta receptor 1 |
| ALIASES | AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-I. |
| NCBI_ENTREZ_NO | 7046 |
| UNIPROT_ACCESS_NO | P36897 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Asthma |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE18965 |
| COMMENTS | TGFBR1 was up regulated in atopic asthmatics as compared to healthy control. |
| REFERENCE | 25515564 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Protein kinase activity, protein serine/threonine kinase activity, transmembrane receptor protein serine/threonine kinase activity, contributes_to transforming growth factor beta-activated receptor activity, transforming growth factor beta receptor activity (type I), signaling receptor binding, type II transforming growth factor beta receptor binding, protein binding, ATP binding, kinase activity, transferase activity, contributes to growth factor binding, SMAD binding, metal ion binding, activin binding, transforming growth factor beta binding, I-SMAD binding. |
| GO_BIOLOGICAL_PROCESS | Activation of MAPKK activity, skeletal system development, angiogenesis, in utero embryonic development, kidney development, blastocyst development, epithelial to mesenchymal transition, negative regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation, lens development in camera-type eye, ventricular trabecula myocardium morphogenesis, ventricular compact myocardium morphogenesis, NOT proepicardium development, regulation of DNA-templated transcription, protein phosphorylation, apoptotic process, cell cycle arrest, signal transduction, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, pattern specification process, heart development, positive regulation of cell proliferation, germ cell migration, male gonad development, post-embryonic development, anterior/posterior pattern specification, regulation of gene expression, positive regulation of gene expression, regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition, positive regulation of pathway-restricted SMAD protein phosphorylation, phosphorylation, protein deubiquitination, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, cell differentiation, collagen fibril organization, positive regulation of cell growth, positive regulation of cell migration, negative regulation of transforming growth factor beta receptor signaling pathway, regulation of protein ubiquitination, negative regulation of chondrocyte differentiation, activin receptor signaling pathway, intracellular signal transduction, regulation of growth, wound healing, endothelial cell activation, extracellular structure organization, positive regulation of apoptotic process, negative regulation of apoptotic process, regulation of protein binding, endothelial cell migration, positive regulation of DNA-templated transcription, thymus development, neuron fate commitment, embryonic cranial skeleton morphogenesis, skeletal system morphogenesis, mesenchymal cell differentiation, artery morphogenesis, cell motility, positive regulation of cellular component movement, positive regulation of filopodium assembly, positive regulation of stress fiber assembly, positive regulation of protein kinase B signaling, parathyroid gland development, roof of mouth development, pharyngeal system development, regulation of cardiac muscle cell proliferation, cardiac epithelial to mesenchymal transition, pathway-restricted SMAD protein phosphorylation, positive regulation of SMAD protein signal transduction, ventricular septum morphogenesis, angiogenesis involved in coronary vascular morphogenesis, coronary artery morphogenesis, response to cholesterol, cellular response to transforming growth factor beta stimulus, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of tight junction disassembly, epicardium morphogenesis, positive regulation of apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 112904 |
| SNP_ID | - |
| DRUG_ID | 4202 4203 |
| STRUCTURE_ID | 204015 204016 204017 204018 |
| MONOCLONAL_ANTIBODY | Anti-TGF beta Receptor I antibody for Human. |