Record No:1
| ACCESS NO | D103348 |
| GENE_NAME | SMAD5 |
| DESCRIPTION | SMAD family member 5 |
| ALIASES | DWFC, JV5-1, MADH5. |
| NCBI_ENTREZ_NO | 4090 |
| UNIPROT_ACCESS_NO | Q99717 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Asthma |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE18965 |
| COMMENTS | SMAD5 was up regulated in atopic asthmatics as compared to healthy control. |
| REFERENCE | 25515564 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity ( sequence-specific DNA binding), DNA binding, DNA binding transcription factor activity, obsolete signal transducer activity ( downstream of receptor), protein binding, DEAD/H-box RNA helicase binding, transforming growth factor beta receptor ( pathway-specific cytoplasmic mediator activity), ubiquitin protein ligase binding, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, ossification, ureteric bud development, Mullerian duct regression, osteoblast fate commitment, DNA-templated transcription, regulation of DNA-templated transcription, protein phosphorylation, signal transduction, transforming growth factor beta receptor signaling pathway, germ cell development, embryonic pattern specification, erythrocyte differentiation, BMP signaling pathway, positive regulation of osteoblast differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, cartilage development, cardiac muscle contraction, bone development, SMAD protein signal transduction, cellular response to organic cyclic compound, cellular response to BMP stimulus, positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus. |
| BIOGRID_INTERACTION_ID | 110402 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 202512 |
| MONOCLONAL_ANTIBODY | Anti-SMAD1+SMAD5 antibody for Rat, Human; Anti-SMAD5 (phospho S463 + S465) antibody for Mouse, Rat, Human; Anti-SMAD5 antibody for Rat, Human, African green monkey. |