Record No:1
| ACCESS NO | D104320 |
| GENE_NAME | TGFB1 |
| DESCRIPTION | Transforming growth factor beta 1 |
| ALIASES | CED, DPD1, LAP, TGFB, TGFbeta. |
| NCBI_ENTREZ_NO | 7040 |
| UNIPROT_ACCESS_NO | P01137 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Primary Airway Epithelial Cells (pAECs) |
| TECHNIQUES | ELISA, qRT-PCR |
| OMICS | Others, Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | TGFB1 gene and protein expression were significantly downregulated in asthmatic pAEC over the course of repair, compared with cells from non-asthmatic children. TGFB1 plays a role in maintaining normal airway epithelium homeostasis and demonstrated that the downregulation of TGFB1 can contribute to dysregulated repair observed in asthmatic airway epithelium. |
| REFERENCE | 27221564 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Antigen binding, type II transforming growth factor beta receptor binding, cytokine activity, transforming growth factor beta receptor binding, protein binding, growth factor activity, enzyme binding, type I transforming growth factor beta receptor binding, type III transforming growth factor beta receptor binding, identical protein binding, protein homodimerization activity, protein serine/threonine kinase activator activity, protein heterodimerization activity, protein N-terminus binding, BMP receptor binding. |
| GO_BIOLOGICAL_PROCESS | Protein import into nucleus ( translocation), negative regulation of transcription by RNA polymerase II, MAPK cascade, vasculogenesis, ureteric bud development, response to hypoxia, morphogenesis of a branching structure, cell activation, epithelial to mesenchymal transition, neural tube closure, negative regulation of protein phosphorylation, positive regulation of protein phosphorylation, regulation of sodium ion transport, chondrocyte differentiation, hematopoietic progenitor cell differentiation, connective tissue replacement involved in inflammatory response wound healing, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, tolerance induction to self antigen, platelet degranulation, heart valve morphogenesis, protein phosphorylation, protein export from nucleus, ATP biosynthetic process, phosphate-containing compound metabolic process, cellular calcium ion homeostasis, inflammatory response, cell cycle arrest, mitotic cell cycle checkpoint, epidermal growth factor receptor signaling pathway, transforming growth factor beta receptor signaling pathway, common-partner SMAD protein phosphorylation, SMAD protein complex assembly, Notch signaling pathway, negative regulation of neuroblast proliferation, salivary gland morphogenesis, endoderm development, heart development, female pregnancy, aging, negative regulation of DNA replication, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, germ cell migration, response to radiation, response to wounding, response to glucose, defense response to fungus ( incompatible interaction), response to organic substance, regulation of gene expression, regulation of signaling receptor activity, positive regulation of vascular endothelial growth factor production, positive regulation of gene expression, negative regulation of gene expression, negative regulation of extracellular matrix disassembly, positive regulation of epithelial to mesenchymal transition, macrophage derived foam cell differentiation, positive regulation of fibroblast migration, positive regulation of peptidyl-threonine phosphorylation, positive regulation of pathway-restricted SMAD protein phosphorylation, negative regulation of macrophage cytokine production, oligodendrocyte development, response to organic cyclic compound, cell growth, regulation of striated muscle tissue development, cell migration, regulation of transforming growth factor beta receptor signaling pathway, evasion or tolerance of host defenses by virus, cytokine-mediated signaling pathway, neural tube development, negative regulation of cell-cell adhesion, hyaluronan catabolic process, T cell differentiation, negative regulation of ossification, negative regulation of cell growth, osteoclast differentiation, regulation of cell migration, positive regulation of cell migration, positive regulation of bone mineralization, BMP signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, mammary gland development, positive regulation of histone deacetylation, animal organ regeneration, membrane protein intracellular domain proteolysis, positive regulation of protein complex assembly, positive regulation of exit from mitosis, lipopolysaccharide-mediated signaling pathway, positive regulation of cellular protein metabolic process, response to estradiol, response to progesterone, regulation of interleukin-23 production, negative regulation of interleukin-17 production, positive regulation of interleukin-17 production, receptor catabolic process, positive regulation of superoxide anion generation, mononuclear cell proliferation, positive regulation of collagen biosynthetic process, positive regulation of peptidyl-serine phosphorylation, response to vitamin D, response to laminar fluid shear stress, positive regulation of histone acetylation, positive regulation of protein dephosphorylation, response to immobilization stress, wound healing, T cell activation, regulation of cell proliferation, negative regulation of T cell proliferation, regulation of protein import into nucleus, positive regulation of protein import into nucleus, positive regulation of odontogenesis, response to drug, myelination, regulation of apoptotic process, myeloid dendritic cell differentiation, T cell homeostasis, positive regulation of apoptotic process, positive regulation of vascular permeability, positive regulation of MAP kinase activity, regulation of MAPK cascade, protein kinase B signaling, positive regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell migration, positive regulation of phosphatidylinositol 3-kinase activity, ossification involved in bone remodeling, regulatory T cell differentiation, cell-cell junction organization, regulation of regulatory T cell differentiation, positive regulation of regulatory T cell differentiation, negative regulation of cell differentiation, negative regulation of fat cell differentiation, negative regulation of myoblast differentiation, negative regulation of cell cycle, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, negative regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, active induction of host immune response by virus, positive regulation of fibroblast proliferation, positive regulation of isotype switching to IgA isotypes, cell development, lymph node development, digestive tract development, negative regulation of skeletal muscle tissue development, inner ear development, positive regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation, positive regulation of protein secretion, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of phagocytosis, negative regulation of immune response, negative regulation of T cell activation, leukocyte migration, positive regulation of chemotaxis, positive regulation of NF-kappaB transcription factor activity, regulation of binding, regulation of DNA binding, positive regulation of smooth muscle cell differentiation, negative regulation of release of sequestered calcium ion into cytosol, positive regulation of cell division, positive regulation of protein kinase B signaling, ventricular cardiac muscle tissue morphogenesis, regulation of blood vessel remodeling, face |
| BIOGRID_INTERACTION_ID | 112898 |
| SNP_ID | 300092 300290 300550 300551 300674 300644 300891 300902 300903 300904 300905 300906 300907 300908 300909 300910 300911 300912 300913 300943 300944 301047 301050 300269 301097 |
| DRUG_ID | 4063 4064 4065 4066 |
| STRUCTURE_ID | 201891 201892 201893 201894 201895 |
| MONOCLONAL_ANTIBODY | Anti-TGF beta 1 antibody for Sheep, Human, Pig, Mouse, Rat, Rabbit, Cow, Human, Mink. |