Record No:1
| ACCESS NO | D104321 |
| GENE_NAME | SMAD6 |
| DESCRIPTION | SMAD family member 6 |
| ALIASES | AOVD2, HsT17432, MADH6, MADH7. |
| NCBI_ENTREZ_NO | 4091 |
| UNIPROT_ACCESS_NO | O43541 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Primary Airway Epithelial Cells (pAECs) |
| TECHNIQUES | TGFB1 PCR array |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | SMAD6 was upregulated in asthmatic pAECs as compared to non asthmatic pAECs. |
| REFERENCE | 27221564 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA binding, chromatin binding, DNA-binding transcription factor activity, protein binding, transforming growth factor beta receptor (inhibitory cytoplasmic mediator activity), ubiquitin protein ligase binding, type I transforming growth factor beta receptor binding, identical protein binding, transcription regulatory region DNA binding, metal ion binding, co-SMAD binding, I-SMAD binding, R-SMAD binding, type I activin receptor binding. |
| GO_BIOLOGICAL_PROCESS | Ureteric bud development, outflow tract septum morphogenesis, heart valve development, aortic valve morphogenesis, mitral valve morphogenesis, pulmonary valve morphogenesis, ventricular septum development, regulation of DNA-templated transcription, immune response, transforming growth factor beta receptor signaling pathway, zygotic specification of dorsal/ventral axis, negative regulation of cell proliferation, negative regulation of SMAD protein complex assembly, negative regulation of ossification, BMP signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of BMP signaling pathway, cell-substrate adhesion, response to lipopolysaccharide, response to laminar fluid shear stress, aorta development, negative regulation of apoptotic process, response to estrogen, fat cell differentiation, negative regulation of osteoblast differentiation, negative regulation of pathway-restricted SMAD protein phosphorylation, coronary vasculature development, positive regulation of pri-miRNA transcription by RNA polymerase II. |
| BIOGRID_INTERACTION_ID | 110266 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205702 |
| MONOCLONAL_ANTIBODY | - |