Record No:1
| ACCESS NO | D104335 |
| GENE_NAME | APAF1 |
| DESCRIPTION | Apoptotic peptidase activating factor 1 |
| ALIASES | APAF-1, CED4. |
| NCBI_ENTREZ_NO | 317 |
| UNIPROT_ACCESS_NO | O14727 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Asthma (AA) |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | APAF1 was underexpressed in severe AA patients as compared to control group. |
| REFERENCE | 28011367 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Nucleotide binding, protein binding, ATP binding, cysteine-type endopeptidase activator activity involved in apoptotic process, heat shock protein binding, identical protein binding, ADP binding. |
| GO_BIOLOGICAL_PROCESS | Response to hypoxia, kidney development, neural tube closure, apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, multicellular organism development, nervous system development, brain development, aging, response to nutrient, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, cardiac muscle cell apoptotic process, cell differentiation, forebrain development, regulation of apoptotic process, positive regulation of apoptotic process, neutrophil degranulation, protein homooligomerization, neuron apoptotic process, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of G0 to G1 transition, cellular response to transforming growth factor beta stimulus, response to G1 DNA damage checkpoint signaling, apoptotic signaling pathway, intrinsic apoptotic signaling pathway, regulation of apoptotic DNA fragmentation, positive regulation of apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 106814 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204270 204271 204272 204273 204274 |
| MONOCLONAL_ANTIBODY | Anti-APAF1 antibody for Human, Rat, Mouse. |