Record No:1
| ACCESS NO | D104355 |
| GENE_NAME | SOS1 |
| DESCRIPTION | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| ALIASES | GF1, GGF1, GINGF, HGF, NS4, SOS-1. |
| NCBI_ENTREZ_NO | 6654 |
| UNIPROT_ACCESS_NO | Q07889 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Asthma (AA) |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | SOS1 was underexpressed in severe AA patients as compared to control group. |
| REFERENCE | 28011367 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | DNA binding, guanyl-nucleotide exchange factor activity, Ras guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, GTPase activator activity, protein binding, SH3 domain binding, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, B cell homeostasis, hair follicle development, lymphocyte homeostasis, heart morphogenesis, cardiac atrium morphogenesis, pericardium morphogenesis, signal transduction, epidermal growth factor receptor signaling pathway, G protein-coupled receptor signaling pathway, small GTPase mediated signal transduction, Ras protein signal transduction, vitellogenesis, axon guidance, insulin receptor signaling pathway, cytokine-mediated signaling pathway, regulation of T cell differentiation in thymus, regulation of Rho protein signal transduction, multicellular organism growth, Fc-epsilon receptor signaling pathway, ERBB2 signaling pathway, regulation of T cell proliferation, positive regulation of apoptotic process, positive regulation of GTPase activity, positive regulation of epidermal growth factor receptor signaling pathway, neurotrophin TRK receptor signaling pathway, blood vessel morphogenesis, leukocyte migration, regulation of small GTPase mediated signal transduction, positive regulation of small GTPase mediated signal transduction, roof of mouth development, eyelid development in camera-type eye, heart trabecula morphogenesis, midbrain morphogenesis, regulation of pro-B cell differentiation. |
| BIOGRID_INTERACTION_ID | 112537 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204260 204261 204262 204263 204264 204265 204266 |
| MONOCLONAL_ANTIBODY | Anti-SOS1 antibody for Human, Mouse, Rat. |