Record No:1
| ACCESS NO | D104441 |
| GENE_NAME | TRAIL |
| DESCRIPTION | TNF superfamily member 10 |
| ALIASES | APO2L, Apo-2L, CD253, TL2, TNLG6A, TNFSF10. |
| NCBI_ENTREZ_NO | 8743 |
| UNIPROT_ACCESS_NO | P50591 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis (AD) |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs), Skin Biopsies |
| TECHNIQUES | Flow Cytometry, Confocal Microscopy |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | An increased expression of TRAIL was observed in peripheral blood T cells and monocytes from patients with atopic dermatitis (AD) compared with control individuals. High TRAIL expression was also observed in skin-infiltrating T cells of AD patients. |
| REFERENCE | 16185275 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Signaling receptor binding, cytokine activity, tumor necrosis factor receptor binding, protein binding, zinc ion binding, tumor necrosis factor receptor superfamily binding, identical protein binding, TRAIL binding, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, immune response, signal transduction, cell surface receptor signaling pathway, cell-cell signaling, male gonad development, response to insulin, positive regulation of apoptotic process, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of release of cytochrome c from mitochondria, regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of extrinsic apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 114280 |
| SNP_ID | 300980 300981 300982 300983 |
| DRUG_ID | 4126 |
| STRUCTURE_ID | 204254 204255 |
| MONOCLONAL_ANTIBODY | Anti-TRAIL antibody for Human, Mouse. |