Record No:1
| ACCESS NO | D104609 |
| GENE_NAME | SIRT1 |
| DESCRIPTION | Sirtuin 1 |
| ALIASES | SIR2, SIR2L1, SIR2alpha. |
| NCBI_ENTREZ_NO | 23411 |
| UNIPROT_ACCESS_NO | Q96EB6 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Severe Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | Fluor-de-lys SIRT1 fluorometric drug discovery assay, Western Blotting |
| OMICS | Others, Proteomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | SIRT1 expression and its deacetylase activity was found to be decreased in PBMCs from patients with severe asthma when compared with those of patients with nonsevere asthma and healthy subjects. Decreased SIRT1 activity was also positively correlated with decreased FEV1. A strong negative correlation between SIRT1 activity and expression of IL4 transcripts in PBMCs. |
| REFERENCE | 26627546 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II distal enhancer sequence-specific DNA binding, DNA-binding transcription activator activity (RNA polymerase II-specific), p53 binding, transcription corepressor activity, NOT NAD+ ADP-ribosyltransferase activity, histone deacetylase activity, protein binding, protein C-terminus binding, transcription factor binding, hydrolase activity, NAD-dependent histone deacetylase activity, deacetylase activity, enzyme binding, protein domain specific binding, protein deacetylase activity, NAD-dependent protein deacetylase activity, nuclear hormone receptor binding, histone binding, identical protein binding, HLH domain binding, bHLH transcription factor binding, metal ion binding, NAD-dependent histone deacetylase activity (H3-K9 specific), mitogen-activated protein kinase binding, NAD+ binding, keratin filament binding. |
| GO_BIOLOGICAL_PROCESS | Single strand break repair, negative regulation of transcription by RNA polymerase II, chromatin silencing at rDNA, pyrimidine dimer repair by nucleotide-excision repair, DNA synthesis involved in DNA repair, angiogenesis, ovulation from ovarian follicle, cellular glucose homeostasis, positive regulation of protein phosphorylation, positive regulation of endothelial cell proliferation, positive regulation of adaptive immune response, chromatin organization, establishment of chromatin silencing, maintenance of chromatin silencing, methylation-dependent chromatin silencing, NOT protein ADP-ribosylation, protein deacetylation, triglyceride mobilization, apoptotic process, cellular response to DNA damage stimulus, response to oxidative stress, transforming growth factor beta receptor signaling pathway, multicellular organism development, spermatogenesis, regulation of mitotic cell cycle, muscle organ development, cell aging, circadian rhythm, positive regulation of cell proliferation, intrinsic apoptotic signaling pathway in response to DNA damage, cellular response to starvation, negative regulation of gene expression, positive regulation of cholesterol efflux, regulation of lipid storage, regulation of glucose metabolic process, macrophage cytokine production, positive regulation of phosphatidylinositol 3-kinase signaling, viral process, positive regulation of macroautophagy, protein ubiquitination, histone deacetylation, peptidyl-lysine acetylation, cell differentiation, macrophage differentiation, negative regulation of cell growth, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of prostaglandin biosynthetic process, protein destabilization, positive regulation of chromatin silencing, negative regulation of TOR signaling, regulation of endodeoxyribonuclease activity, negative regulation of NF-kappaB transcription factor activity, response to insulin, circadian regulation of gene expression, leptin-mediated signaling pathway, regulation of smooth muscle cell apoptotic process, peptidyl-lysine deacetylation, cellular triglyceride homeostasis, regulation of peroxisome proliferator activated receptor signaling pathway, regulation of cell proliferation, negative regulation of phosphorylation, response to hydrogen peroxide, behavioral response to starvation, cholesterol homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, regulation of apoptotic process, positive regulation of apoptotic process, negative regulation of apoptotic process, negative regulation of I-kappaB kinase/NF-kappaB signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of DNA-binding transcription factor activity, negative regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of blood vessel endothelial cell migration, response to leptin, positive regulation of MHC class II biosynthetic process, negative regulation of fat cell differentiation, positive regulation of gluconeogenesis, positive regulation of DNA repair, positive regulation of angiogenesis, negative regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of insulin receptor signaling pathway, rhythmic process, white fat cell differentiation, negative regulation of helicase activity, positive regulation of smooth muscle cell differentiation, positive regulation of histone H3-K9 methylation, negative regulation of protein kinase B signaling, fatty acid homeostasis, negative regulation of androgen receptor signaling pathway, histone H3-K9 modification, cellular response to hydrogen peroxide, regulation of bile acid biosynthetic process, UV-damage excision repair, histone H3 deacetylation, cellular response to tumor necrosis factor, negative regulation of histone H3-K14 acetylation, cellular response to hypoxia, cellular response to ionizing radiation, regulation of protein serine/threonine kinase activity, regulation of brown fat cell differentiation, stress-induced premature senescence, regulation of cellular response to heat, negative regulation of histone H3-K9 trimethylation, negative regulation of neuron death, negative regulation of protein acetylation, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of adipose tissue development, histone H3-K9 deacetylation, cellular response to leukemia inhibitory factor, positive regulation of macrophage apoptotic process, negative regulation of cAMP-dependent protein kinase activity, positive regulation of cAMP-dependent protein kinase activity, negative regulation of histone H4-K16 acetylation, negative regulation of cellular response to testosterone stimulus, negative regulation of peptidyl-lysine acetylation, negative regulation of cellular senescence, positive regulation of cellular senescence. |
| BIOGRID_INTERACTION_ID | 116983 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204465 204466 204467 |
| MONOCLONAL_ANTIBODY | Anti-SIRT1 antibody for Mouse, Human, Rat; Anti-SIRT1 (phospho T530) antibody for Human; Anti-SIRT1 (phospho S27) antibody for Human; Anti-SIRT1 (phospho S47) antibody for Human. |