Record No:1
| ACCESS NO | D105155 |
| GENE_NAME | IL8 |
| DESCRIPTION | Interleukin 8 |
| ALIASES | GCP-1, GCP1, CXCL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1. |
| NCBI_ENTREZ_NO | 3576 |
| UNIPROT_ACCESS_NO | P10145 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs), Serum |
| TECHNIQUES | qRT-PCR, ELISA |
| OMICS | Genomics, Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | The IL8 expression at both protein and mRNA levels was found to be significantly elevated in asthmatic children compared to healthy subjects. Both IL8 gene and protein expression may play a key role in asthma pathogenesis. |
| REFERENCE | 28993876 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interleukin-8 receptor binding, protein binding, chemokine activity, CXCR chemokine receptor binding. |
| GO_BIOLOGICAL_PROCESS | Angiogenesis, response to molecule of bacterial origin, positive regulation of leukocyte chemotaxis, chemotaxis, defense response, inflammatory response, immune response, cell cycle arrest, signal transduction, G-protein coupled receptor signaling pathway, negative regulation of cell proliferation, regulation of signaling receptor activity, cytokine-mediated signaling pathway, calcium-mediated signaling, regulation of cell adhesion, neutrophil chemotaxis, receptor internalization, response to lipopolysaccharide, response to endoplasmic reticulum stress, intracellular signal transduction, PERK-mediated unfolded protein response, neutrophil activation, regulation of cell proliferation, cellular response to fibroblast growth factor stimulus, regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of G-protein coupled receptor protein signaling pathway, positive regulation of angiogenesis, embryonic digestive tract development, induction of positive chemotaxis, chemokine-mediated signaling pathway, cellular response to lipopolysaccharide, cellular response to interleukin-1, cellular response to tumor necrosis factor, positive regulation of neutrophil chemotaxis, regulation of entry of bacterium into host cell. |
| BIOGRID_INTERACTION_ID | 109790 |
| SNP_ID | 300230 301032 301033 301034 301035 301036 300231 |
| DRUG_ID | - |
| STRUCTURE_ID | 200306 200307 200308 200309 200310 200311 200312 200313 |
| MONOCLONAL_ANTIBODY | Anti-IL-8 antibody for Human, Sheep, Rabbit, Cow, Dog, Pig. |