Record No:1
| ACCESS NO | D106315 |
| GENE_NAME | KDM2B |
| DESCRIPTION | Lysine demethylase 2B |
| ALIASES | CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2. |
| NCBI_ENTREZ_NO | 84678 |
| UNIPROT_ACCESS_NO | Q8NHM5 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Childhood Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE96783 |
| COMMENTS | KDM2B was up regulated in asthmatics as compared to healthy controls. |
| REFERENCE | 29518416 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, DNA binding, RNA binding, protein binding, zinc ion binding, oxidoreductase activity, rRNA binding, histone demethylase activity, unmethylated CpG binding, metal ion binding, dioxygenase activity, histone demethylase activity (H3-K36 specific). |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, chromatin organization, spermatogenesis, midbrain-hindbrain boundary morphogenesis, fourth ventricle development, lateral ventricle development, third ventricle development, initiation of neural tube closure, positive regulation of cell growth, forebrain development, midbrain development, hindbrain development, histone H2A monoubiquitination, negative regulation of neuron apoptotic process, embryonic camera-type eye morphogenesis, oxidation-reduction process, histone H3-K36 demethylation, positive regulation of stem cell population maintenance, negative regulation of neural precursor cell proliferation. |
| BIOGRID_INTERACTION_ID | 124197 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 208005 |
| MONOCLONAL_ANTIBODY | Anti-KDM2B antibody for Human. |