Record No:1
| ACCESS NO | D106511 |
| GENE_NAME | miR-221-3p |
| DESCRIPTION | MicroRNA 221 |
| ALIASES | MIRN221, miRNA221, mir-221, miR-221, MIR221. |
| NCBI_ENTREZ_NO | 407006 |
| UNIPROT_ACCESS_NO | - |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Bronchial Brushings, Induced Sputum, Blood Plasma |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Epithelial, sputum, and plasma miR-221-3p expression was significantly decreased in subjects with asthma. Decreased epithelial miR-221-3p may protect against airway eosinophilic inflammation by upregulating anti-inflammatory chemokine CXCL17. |
| REFERENCE | 29644894 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | mRNA binding involved in posttranscriptional gene silencing. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of cell proliferation, response to glucose, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, negative regulation of heterotypic cell-cell adhesion, gene silencing by miRNA, miRNA mediated inhibition of translation, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of apoptotic process, negative regulation of apoptotic process, positive regulation of blood vessel endothelial cell migration, negative regulation by host of viral genome replication, positive regulation of erythrocyte differentiation, positive regulation of JAK-STAT cascade, platelet-derived growth factor receptor signaling pathway, positive regulation of axon regeneration, negative regulation of inflammatory response, positive regulation of protein kinase B signaling, negative regulation of cell adhesion molecule production, negative regulation of ERK1 and ERK2 cascade, positive regulation of ERK1 and ERK2 cascade, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cytokine production involved in inflammatory response, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of Schwann cell migration, negative regulation of hematopoietic stem cell proliferation, negative regulation of TRAIL-activated apoptotic signaling pathway, negative regulation of sprouting angiogenesis, positive regulation of wound healing ( spreading of epidermal cells), positive regulation of vascular smooth muscle cell proliferation, positive regulation of vascular associated smooth muscle cell migration, negative regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of Schwann cell proliferation involved in axon regeneration, negative regulation of vascular smooth muscle cell differentiation, positive regulation of vascular smooth muscle cell dedifferentiation, negative regulation of double-strand break repair. |
| BIOGRID_INTERACTION_ID | 135855 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | - |
| MONOCLONAL_ANTIBODY | - |