Record No:1
| ACCESS NO | D106761 |
| GENE_NAME | S1PR1 |
| DESCRIPTION | Sphingosine-1-phosphate receptor 1 |
| ALIASES | CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1. |
| NCBI_ENTREZ_NO | 1901 |
| UNIPROT_ACCESS_NO | P21453 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Brushings |
| TECHNIQUES | RNA Sequencing |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | S1PR1 was significantly up regulated in asthmatics as compared to control group. |
| REFERENCE | 29064281 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | G protein-coupled receptor binding, G protein-coupled receptor activity, protein binding, sphingosine-1-phosphate receptor activity, sphingolipid binding. |
| GO_BIOLOGICAL_PROCESS | Angiogenesis, blood vessel maturation, cardiac muscle tissue growth involved in heart morphogenesis, sphingosine-1-phosphate receptor signaling pathway, chemotaxis, cell adhesion, signal transduction, G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, brain development, positive regulation of cell proliferation, cell migration, cytokine-mediated signaling pathway, regulation of metabolic process, transmission of nerve impulse, lamellipodium assembly, regulation of cell adhesion, neuron differentiation, positive regulation of cell migration, regulation of bone mineralization, leukocyte chemotaxis, actin cytoskeleton reorganization, positive regulation of GTPase activity, regulation of bone resorption, endothelial cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of smooth muscle cell proliferation, positive regulation of positive chemotaxis, positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway, negative regulation of stress fiber assembly, heart trabecula morphogenesis, T cell migration. |
| BIOGRID_INTERACTION_ID | 108225 |
| SNP_ID | - |
| DRUG_ID | 4112 4113 |
| STRUCTURE_ID | 208599 208600 |
| MONOCLONAL_ANTIBODY | Anti-S1P1/EDG1 antibody for Human. |