Record No:1


ACCESS NOD106767
GENE_NAMESOCS1
DESCRIPTIONSuppressor of cytokine signaling 1
ALIASESCIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3.
NCBI_ENTREZ_NO8651
UNIPROT_ACCESS_NOO15524
ORGANISMHuman
DISEASE_PHENOTYPEAsthma
SAMPLEAirway Epithelial Brushings
TECHNIQUESRNA Sequencing
OMICSGenomics
STUDYHigh Throughput
GEO_PRIDE_ACCESS_NONA
COMMENTSSOCS1 was significantly up regulated in asthmatics as compared to control group.
REFERENCE29064281
IMMUNITY_TERMYes
GO_MOLECULAR_FUNCTIONProtein kinase inhibitor activity, insulin-like growth factor receptor binding, protein binding, kinase inhibitor activity, protein kinase binding, 1-phosphatidylinositol-3-kinase regulator activity.
GO_BIOLOGICAL_PROCESSRegulation of protein phosphorylation, negative regulation of protein kinase activity, JAK-STAT cascade, negative regulation of signal transduction, regulation of activation of Janus kinase activity, protein ubiquitination, cytokine-mediated signaling pathway, negative regulation of kinase activity, intracellular signal transduction, interleukin-7-mediated signaling pathway, regulation of growth, regulation of tyrosine phosphorylation of STAT protein, negative regulation of tyrosine phosphorylation of STAT protein, positive regulation of CD4-positive alpha-beta T cell differentiation, negative regulation of CD8-positive alpha-beta T cell differentiation, regulation of phosphatidylinositol 3-kinase activity, fat cell differentiation, positive regulation of regulatory T cell differentiation, regulation of JAK-STAT cascade, negative regulation of JAK-STAT cascade, negative regulation of insulin receptor signaling pathway, phosphatidylinositol phosphorylation, regulation of cytokine secretion, regulation of interferon-gamma-mediated signaling pathway, cellular response to amino acid stimulus.
BIOGRID_INTERACTION_ID114203
SNP_ID300861
300862
DRUG_ID-
STRUCTURE_ID204352
MONOCLONAL_ANTIBODY-

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