Record No:1
| ACCESS NO | D106889 |
| GENE_NAME | miR-181b-5p |
| DESCRIPTION | MicroRNA 181b |
| ALIASES | MIR181B1, MIRN181B1, mir-181b-1, MIRN181B2, mir-181b-2, MIR181B2. |
| NCBI_ENTREZ_NO | 406955, 406956 |
| UNIPROT_ACCESS_NO | - |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Epithelial Brushings, Blood Plasma |
| TECHNIQUES | Microarray, qRT-PCR |
| OMICS | Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Epithelial miR-181b-5p expression was decreased in subjects with asthma. Epithelial miR-181b-5p levels were inversely correlated with sputum and bronchial submucosal eosinophilia. Plasma miR-181b-5p was decreased and correlated with epithelial miR-181b-5p in subjects with asthma. Epithelial and plasma miR-181b-5p are potential biomarkers for airway eosinophilia in asthma. |
| REFERENCE | 27192552 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | mRNA binding involved in posttranscriptional gene silencing. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of signal transduction, negative regulation of keratinocyte proliferation, negative regulation of mitochondrial membrane potential, positive regulation of cell migration, negative regulation of toll-like receptor 4 signaling pathway, gene silencing by miRNA, miRNA mediated inhibition of translation, positive regulation of nitric oxide biosynthetic process, positive regulation of endothelial cell differentiation, positive regulation of angiogenesis, negative regulation of innate immune response, negative regulation of inflammatory response, positive regulation of inflammatory response, negative regulation of phagocytosis, negative regulation of astrocyte activation, cellular response to tumor necrosis factor, positive regulation of elastin catabolic process, positive regulation of macrophage proliferation, negative regulation of defense response to bacterium, positive regulation of p38MAPK cascade, positive regulation of fibroblast apoptotic process. |
| BIOGRID_INTERACTION_ID | 135804, 135805 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | - |
| MONOCLONAL_ANTIBODY | - |