Record No:1
| ACCESS NO | D106962 |
| GENE_NAME | SOCS1 |
| DESCRIPTION | Suppressor of cytokine signaling 1 |
| ALIASES | CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3. |
| NCBI_ENTREZ_NO | 8651 |
| UNIPROT_ACCESS_NO | O15524 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Asthma (following allergen bronchoprovocation test with HDM) |
| SAMPLE | Induced Sputum |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | SOCS1 gene expression was up regulated by allergen challenge and was down regulated by fluticasone treatment. |
| REFERENCE | 27421833 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protein kinase inhibitor activity, insulin-like growth factor receptor binding, protein binding, kinase inhibitor activity, protein kinase binding, 1-phosphatidylinositol-3-kinase regulator activity. |
| GO_BIOLOGICAL_PROCESS | Regulation of protein phosphorylation, negative regulation of protein kinase activity, JAK-STAT cascade, negative regulation of signal transduction, regulation of activation of Janus kinase activity, protein ubiquitination, cytokine-mediated signaling pathway, negative regulation of kinase activity, intracellular signal transduction, interleukin-7-mediated signaling pathway, regulation of growth, regulation of tyrosine phosphorylation of STAT protein, negative regulation of tyrosine phosphorylation of STAT protein, positive regulation of CD4-positive alpha-beta T cell differentiation, negative regulation of CD8-positive alpha-beta T cell differentiation, regulation of phosphatidylinositol 3-kinase activity, fat cell differentiation, positive regulation of regulatory T cell differentiation, regulation of JAK-STAT cascade, negative regulation of JAK-STAT cascade, negative regulation of insulin receptor signaling pathway, phosphatidylinositol phosphorylation, regulation of cytokine secretion, regulation of interferon-gamma-mediated signaling pathway, cellular response to amino acid stimulus. |
| BIOGRID_INTERACTION_ID | 114203 |
| SNP_ID | 300861 300862 |
| DRUG_ID | - |
| STRUCTURE_ID | 204352 |
| MONOCLONAL_ANTIBODY | - |