Record No:1
| ACCESS NO | D107133 |
| GENE_NAME | JAK2 |
| DESCRIPTION | Janus kinase 2 |
| ALIASES | JTK10, THCYT3. |
| NCBI_ENTREZ_NO | 3717 |
| UNIPROT_ACCESS_NO | O60674 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | Microarray Data Analysis |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE68479, GSE19301 |
| COMMENTS | JAK2 was up regulated in asthmatics with multiple asthma exacerbations triggered by respiratory infections (AETRI). |
| REFERENCE | 29486764 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Nucleotide binding, protein kinase activity, protein tyrosine kinase activity, non-membrane spanning protein tyrosine kinase activity, Ras guanyl-nucleotide exchange factor activity, signaling receptor binding, growth hormone receptor binding, interleukin-12 receptor binding, protein binding, ATP binding, protein C-terminus binding, kinase activity, transferase activity, protein kinase binding, heme binding, type 1 angiotensin receptor binding, acetylcholine receptor binding, histone kinase activity (H3-Y41 specific), SH2 domain binding, histone binding, identical protein binding, phosphatidylinositol 3-kinase binding, insulin receptor substrate binding, metal ion binding, peptide hormone receptor binding. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, activation of MAPKK activity, adaptive immune response, immune system process, chromatin organization, protein phosphorylation, apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, response to oxidative stress, signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, G-protein coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, JAK-STAT cascade, tyrosine phosphorylation of STAT protein, mesoderm development, blood coagulation, positive regulation of cell proliferation, negative regulation of cell proliferation, intrinsic apoptotic signaling pathway in response to oxidative stress, hormone-mediated signaling pathway, negative regulation of cardiac muscle cell apoptotic process, positive regulation of cell-substrate adhesion, positive regulation of phosphatidylinositol 3-kinase signaling, phosphorylation, cell migration, peptidyl-tyrosine phosphorylation, cytokine-mediated signaling pathway, negative regulation of cell-cell adhesion, actin filament polymerization, cell differentiation, regulation of cell adhesion, erythrocyte differentiation, positive regulation of cell migration, axon regeneration, mineralocorticoid receptor signaling pathway, positive regulation of insulin secretion, response to lipopolysaccharide, positive regulation of phosphoprotein phosphatase activity, positive regulation of interleukin-1 beta production, positive regulation of tumor necrosis factor production, positive regulation of protein import into nucleus ( translocation), response to hydroperoxide, tumor necrosis factor-mediated signaling pathway, response to tumor necrosis factor, histone H3-Y41 phosphorylation, intracellular signal transduction, interleukin-12-mediated signaling pathway, peptidyl-tyrosine autophosphorylation, interleukin-23-mediated signaling pathway, regulation of cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, activation of Janus kinase activity, regulation of apoptotic process, positive regulation of apoptotic process, positive regulation of DNA binding, negative regulation of DNA binding, negative regulation of neuron apoptotic process, innate immune response, positive regulation of nitric oxide biosynthetic process, positive regulation of cell differentiation, negative regulation of heart contraction, regulation of JAK-STAT cascade, response to antibiotic, protein autophosphorylation, platelet-derived growth factor receptor signaling pathway, regulation of inflammatory response, positive regulation of inflammatory response, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of cell activation, positive regulation of DNA binding transcription factor activity, positive regulation of nitric-oxide synthase biosynthetic process, interferon-gamma-mediated signaling pathway, regulation of interferon-gamma-mediated signaling pathway, growth hormone receptor signaling pathway, JAK-STAT cascade involved in growth hormone signaling pathway, positive regulation of growth hormone receptor signaling pathway, negative regulation of cell death, mammary gland epithelium development, interleukin-6-mediated signaling pathway, interleukin-27-mediated signaling pathway, response to interleukin-12, interleukin-35-mediated signaling pathway, extrinsic apoptotic signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of epithelial cell apoptotic process, positive regulation of vascular smooth muscle cell proliferation. |
| BIOGRID_INTERACTION_ID | 109920 |
| SNP_ID | 300097 |
| DRUG_ID | 4312 4313 4315 4318 |
| STRUCTURE_ID | 202876 202877 202878 |
| MONOCLONAL_ANTIBODY | Anti-JAK2 antibody for Mouse, Rat, Human; Anti-JAK2 (phospho Y1007 + Y1008) antibody for Mouse, Rat, Human. |