Record No:1
| ACCESS NO | D107150 |
| GENE_NAME | PIK3R1 |
| DESCRIPTION | Phosphoinositide-3-kinase regulatory subunit 1 |
| ALIASES | AGM7, GRB1, IMD36, p85, p85-ALPHA. |
| NCBI_ENTREZ_NO | 5295 |
| UNIPROT_ACCESS_NO | P27986 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | Microarray Data Analysis |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE68479, GSE19301 |
| COMMENTS | PIK3R1 was up regulated in asthmatics with multiple asthma exacerbations triggered by respiratory infections (AETRI) but down regulated in asthmatics with single AETRI. |
| REFERENCE | 29486764 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Phosphotyrosine residue binding, transmembrane receptor protein tyrosine kinase adaptor activity, insulin receptor binding, insulin-like growth factor receptor binding, neurotrophin TRKA receptor binding, protein binding, transcription factor binding, 1-phosphatidylinositol-3-kinase activity, protein phosphatase binding, phosphatidylinositol 3-kinase regulator activity, phosphatidylinositol 3-kinase regulatory subunit binding, ErbB-3 class receptor binding, phosphatidylinositol 3-kinase binding, insulin binding, insulin receptor substrate binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | Cellular glucose homeostasis, negative regulation of cell-matrix adhesion, protein phosphorylation, protein import into nucleus, phosphatidylinositol biosynthetic process, negative regulation of cell adhesion, signal transduction, epidermal growth factor receptor signaling pathway, G-protein coupled receptor signaling pathway, axon guidance, insulin receptor signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, intrinsic apoptotic signaling pathway in response to DNA damage, phosphatidylinositol 3-kinase signaling, protein transport, viral process, cytokine-mediated signaling pathway, platelet activation, B cell differentiation, positive regulation of cell migration, T cell costimulation, positive regulation of tumor necrosis factor production, cellular response to insulin stimulus, positive regulation of RNA splicing, cellular response to UV, response to endoplasmic reticulum stress, phosphatidylinositol-3-phosphate biosynthetic process, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, ERBB2 signaling pathway, positive regulation of protein import into nucleus, obsolete positive regulation of transcription factor import into nucleus, negative regulation of apoptotic process, regulation of phosphatidylinositol 3-kinase activity, negative regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of glucose import, regulation of insulin receptor signaling pathway, phosphatidylinositol phosphorylation, insulin-like growth factor receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway, phosphatidylinositol-mediated signaling, protein stabilization, T cell receptor signaling pathway, leukocyte migration, regulation of stress fiber assembly, positive regulation of protein kinase B signaling, growth hormone receptor signaling pathway, positive regulation of endoplasmic reticulum unfolded protein response, regulation of protein localization to plasma membrane, positive regulation of protein localization to plasma membrane, positive regulation of glucose import in response to insulin stimulus. |
| BIOGRID_INTERACTION_ID | 111313 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200889 200890 200891 200892 200893 200894 |
| MONOCLONAL_ANTIBODY | Anti-PI 3 Kinase p85 alpha antibody for Mouse, Rat, Human. |