Record No:1
| ACCESS NO | D107151 |
| GENE_NAME | DYRK2 |
| DESCRIPTION | Dual specificity tyrosine phosphorylation regulated kinase 2 |
| ALIASES | - |
| NCBI_ENTREZ_NO | 8445 |
| UNIPROT_ACCESS_NO | Q92630 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMCs) |
| TECHNIQUES | Microarray Data Analysis |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE68479, GSE19301 |
| COMMENTS | DYRK2 was up regulated in asthmatics with multiple asthma exacerbations triggered by respiratory infections (AETRI) but down regulated in asthmatics with single AETRI. |
| REFERENCE | 29486764 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Nucleotide binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, protein binding, ATP binding, kinase activity, transferase activity, manganese ion binding. |
| GO_BIOLOGICAL_PROCESS | Protein phosphorylation, apoptotic process, cellular response to DNA damage stimulus, smoothened signaling pathway, phosphorylation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, peptidyl-tyrosine phosphorylation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of glycogen biosynthetic process, negative regulation of calcineurin-NFAT signaling cascade, regulation of signal transduction by p53 class mediator. |
| BIOGRID_INTERACTION_ID | 114023 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 209703 |
| MONOCLONAL_ANTIBODY | - |