Record No:1
| ACCESS NO | D107247 |
| GENE_NAME | FOXO3 |
| DESCRIPTION | Forkhead box O3 |
| ALIASES | AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A. |
| NCBI_ENTREZ_NO | 2309 |
| UNIPROT_ACCESS_NO | O43524 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, COPD |
| SAMPLE | Primary Bronchial Epithelial Cells (BECs) |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Significantly decreased expression levels of FOXO3 was noted primary bronchial epthelial cells in asthmatics and COPD patients as compared to healthy subjects. |
| REFERENCE | 30696075 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Transcription regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), transcription cofactor binding, DNA-binding transcription repressor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, protein binding, beta-catenin binding, transcription factor binding, protein kinase binding, chromatin DNA binding, mitochondrial sequence-specific DNA-binding transcription factor activity, sequence-specific DNA binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, ovulation from ovarian follicle, initiation of primordial ovarian follicle growth, antral ovarian follicle growth, oocyte maturation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, mitochondrial transcription, regulation of translation, apoptotic process, aging, insulin receptor signaling pathway, positive regulation of autophagy, positive regulation of muscle atrophy, cytokine-mediated signaling pathway, DNA damage response (signal transduction by p53 class mediator), negative regulation of cell migration, response to nutrient levels, tumor necrosis factor-mediated signaling pathway, cellular response to oxidative stress, cellular response to glucose starvation, response to drug, glucose homeostasis, response to starvation, positive regulation of apoptotic process, positive regulation of neuron apoptotic process, positive regulation of erythrocyte differentiation, negative regulation of neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, brain morphogenesis, response to fatty acid, cellular response to glucose stimulus, cellular response to corticosterone stimulus, cellular response to hypoxia, response to dexamethasone, negative regulation of canonical Wnt signaling pathway, neuronal stem cell population maintenance, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of hydrogen peroxide-mediated programmed cell death, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of reactive oxygen species biosynthetic process, cellular response to amyloid-beta, cellular response to nerve growth factor stimulus, response to water-immersion restraint stress, regulation of neural precursor cell proliferation, positive regulation of endothelial cell apoptotic process, regulation of reactive oxygen species metabolic process. |
| BIOGRID_INTERACTION_ID | 108598 |
| SNP_ID | 300253 |
| DRUG_ID | - |
| STRUCTURE_ID | 209372 209373 209374 209375 209376 |
| MONOCLONAL_ANTIBODY | Anti-FOXO3A antibody for Human, Rat; Anti-FOXO3A (phospho S253) antibody for Human, Mouse, Rat. |