Record No:1
| ACCESS NO | D107389 |
| GENE_NAME | VAV3 |
| DESCRIPTION | Vav guanine nucleotide exchange factor 3 |
| ALIASES | - |
| NCBI_ENTREZ_NO | 10451 |
| UNIPROT_ACCESS_NO | Q9UKW4 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Eosinophilic Asthma, Neutrophilic Asthma |
| SAMPLE | Peripheral Blood |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE106230, GSE117038 |
| COMMENTS | VAV3 was significantly up regulated in neutrophilic asthma as compared to eosinophilic asthma and control group. |
| REFERENCE | 30941157 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | SH3/SH2 adaptor activity, guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, GTPase activator activity, epidermal growth factor receptor binding, protein binding, Rac guanyl-nucleotide exchange factor activity, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Angiogenesis, vesicle fusion, cellular response to DNA damage stimulus, G protein-coupled receptor signaling pathway, integrin-mediated signaling pathway, small GTPase mediated signal transduction, NOT regulation of cell size, positive regulation of signal transduction, cell migration, cell projection assembly, lamellipodium assembly, platelet activation, neutrophil chemotaxis, positive regulation of B cell proliferation, intracellular signal transduction, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, response to drug, positive regulation of apoptotic process, regulation of GTPase activity, positive regulation of GTPase activity, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of cell adhesion, vascular endothelial growth factor receptor signaling pathway, ephrin receptor signaling pathway, B cell receptor signaling pathway, regulation of small GTPase mediated signal transduction. |
| BIOGRID_INTERACTION_ID | 115715 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 209499 |
| MONOCLONAL_ANTIBODY | Anti-VAV3 antibody for Human, Mouse; Anti-VAV3 (phospho Y173) antibody for Human. |