Record No:1
| ACCESS NO | D107521 |
| GENE_NAME | BRCA1 |
| DESCRIPTION | BRCA1 DNA repair associated |
| ALIASES | BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53. |
| NCBI_ENTREZ_NO | 672 |
| UNIPROT_ACCESS_NO | P38398 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Eosinophilic Asthma, Neutrophilic Asthma |
| SAMPLE | Peripheral Blood |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE106230, GSE117038 |
| COMMENTS | BRCA1 was significantly down regulated in eosinophilic asthma as compared to neutrophilic asthma group. |
| REFERENCE | 30941157 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Transcription regulatory region sequence-specific DNA binding, DNA binding, damaged DNA binding, transcription coactivator activity, RNA binding, ubiquitin-protein transferase activity, protein binding, zinc ion binding, tubulin binding, transferase activity, enzyme binding, ubiquitin protein ligase binding, identical protein binding, transcription regulatory region DNA binding, metal ion binding, androgen receptor binding, RNA polymerase binding. |
| GO_BIOLOGICAL_PROCESS | Double-strand break repair via homologous recombination, DNA double-strand break processing, DNA replication, DNA repair, postreplication repair, double-strand break repair, double-strand break repair via nonhomologous end joining, DNA recombination, regulation of gene expression by genetic imprinting, regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase III, lipid metabolic process, fatty acid metabolic process, fatty acid biosynthetic process, apoptotic process, cellular response to DNA damage stimulus, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cell cycle, chromosome segregation, centrosome cycle, intrinsic apoptotic signaling pathway in response to DNA damage, dosage compensation by inactivation of X chromosome, response to ionizing radiation, positive regulation of vascular endothelial growth factor production, positive regulation of gene expression, protein ubiquitination, protein deubiquitination, androgen receptor signaling pathway, positive regulation of protein ubiquitination, negative regulation of intracellular estrogen receptor signaling pathway, positive regulation of histone acetylation, negative regulation of histone acetylation, regulation of cell proliferation, regulation of apoptotic process, chordate embryonic development, response to estrogen, regulation of DNA methylation, mitotic G2/M transition checkpoint, negative regulation of fatty acid biosynthetic process, positive regulation of DNA repair, positive regulation of angiogenesis, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of centriole replication, positive regulation of histone H3-K4 methylation, negative regulation of histone H3-K4 methylation, negative regulation of histone H3-K9 methylation, positive regulation of histone H3-K9 methylation, protein autoubiquitination, negative regulation of G0 to G1 transition, positive regulation of histone H4-K20 methylation, positive regulation of cell cycle arrest, cellular response to tumor necrosis factor, cellular response to indole-3-methanol, signal transduction involved in G2 DNA damage checkpoint, protein K6-linked ubiquitination, regulation of signal transduction by p53 class mediator, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of reactive oxygen species metabolic process, positive regulation of histone H3-K9 acetylation, positive regulation of histone H4-K16 acetylation. |
| BIOGRID_INTERACTION_ID | 107140 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 209618 209619 209620 209621 209622 209623 209624 209625 209626 209627 209628 209629 209630 209631 209632 209633 |
| MONOCLONAL_ANTIBODY | Anti-BRCA1 antibody for Human. |