Record No:1
| ACCESS NO | D108127 |
| GENE_NAME | miR-145 |
| DESCRIPTION | MicroRNA 145 |
| ALIASES | MIRN145, miR-145, miRNA145, MIR145. |
| NCBI_ENTREZ_NO | 406937 |
| UNIPROT_ACCESS_NO | - |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | miR-145 expression was significantly increased in CD4 T cells from asthmatic patients as compared to healthy controls. MicroRNA-145 could regulate the balance of Th1/Th2 through targeting the RUNX3 in asthma patients. MicroRNA-145 may be used as biomarker or target in the diagnosis or therapy of asthma. |
| REFERENCE | 27902892 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II complex binding, mRNA binding involved in posttranscriptional gene silencing. |
| GO_BIOLOGICAL_PROCESS | Regulation of smooth muscle contraction, negative regulation of cardiac muscle hypertrophy, negative regulation of cardiac muscle cell apoptotic process, ectodermal cell differentiation, positive regulation of fibroblast migration, negative regulation of angiogenesis, actin cytoskeleton organization, regulation of collagen biosynthetic process, gene silencing by miRNA, miRNA mediated inhibition of translation, vascular smooth muscle cell differentiation, myofibroblast differentiation, angiotensin-activated signaling pathway, establishment or maintenance of cell type involved in phenotypic switching, mesodermal cell differentiation, negative regulation of smooth muscle cell proliferation, negative regulation of protein kinase B signaling, aorta smooth muscle tissue morphogenesis, regulation of ERK1 and ERK2 cascade, positive regulation of canonical Wnt signaling pathway, regulation of phenotypic switching, negative regulation of somatic stem cell population maintenance, negative regulation of somatic stem cell division, negative regulation of vascular smooth muscle cell dedifferentiation, positive regulation of cardiac vascular smooth muscle cell differentiation. |
| BIOGRID_INTERACTION_ID | 135786 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | - |
| MONOCLONAL_ANTIBODY | - |