Record No:1
| ACCESS NO | D109362 |
| GENE_NAME | CASP2 |
| DESCRIPTION | Caspase 2 |
| ALIASES | CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57. |
| NCBI_ENTREZ_NO | 835 |
| UNIPROT_ACCESS_NO | P42575 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | CASP2 was preferentially upregulated in Th2 memory cells from asthmatic subjects as compared to control subjects and allergic rhinitis patients. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Cysteine-type endopeptidase activity, protein binding, peptidase activity, cysteine-type peptidase activity, hydrolase activity, enzyme binding, protein domain specific binding, identical protein binding, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in execution phase of apoptosis. |
| GO_BIOLOGICAL_PROCESS | Luteolysis, neural retina development, proteolysis, apoptotic process, DNA damage response (signal transduction by p53 class mediator resulting in cell cycle arrest), brain development, aging, intrinsic apoptotic signaling pathway in response to DNA damage, protein processing, ectopic germ cell programmed cell death, regulation of apoptotic process, positive regulation of apoptotic process, negative regulation of apoptotic process, positive regulation of neuron apoptotic process, cellular response to mechanical stimulus, apoptotic signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, execution phase of apoptosis, positive regulation of apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 107285 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205867 |
| MONOCLONAL_ANTIBODY | Anti-Caspase-2 antibody for Human, Mouse, Rat. |