Record No:1
| ACCESS NO | D109367 |
| GENE_NAME | NFKB1 |
| DESCRIPTION | Nuclear factor kappa B subunit 1 |
| ALIASES | CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, NFKB. |
| NCBI_ENTREZ_NO | 4790 |
| UNIPROT_ACCESS_NO | P19838 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | NFKB1 was decreased in asthmatic subjects as compared to that of allergic rhinitis and healthy controls. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Transcription regulatory region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA-binding transcription repressor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, chromatin binding, DNA-binding transcription factor activity, protein binding, transcription factor binding, identical protein binding, protein homodimerization activity, actinin binding, sequence-specific DNA binding, transcription regulatory region DNA binding, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, negative regulation of cytokine production, stimulatory C-type lectin receptor signaling pathway, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, apoptotic process, inflammatory response, signal transduction, I-kappaB kinase/NF-kappaB signaling, negative regulation of gene expression, positive regulation of macrophage derived foam cell differentiation, positive regulation of lipid storage, negative regulation of calcidiol 1-monooxygenase activity, negative regulation of vitamin D biosynthetic process, membrane protein intracellular domain proteolysis, negative regulation of cellular protein metabolic process, negative regulation of cholesterol transport, positive regulation of type I interferon production, response to cytokine, response to muscle stretch, NIK/NF-kappaB signaling, Fc-epsilon receptor signaling pathway, negative regulation of apoptotic process, neutrophil degranulation, negative regulation of interleukin-12 biosynthetic process, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of inflammatory response, T cell receptor signaling pathway, positive regulation of NF-kappaB transcription factor activity, stress-activated MAPK cascade, interleukin-1-mediated signaling pathway, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to nicotine, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to tumor necrosis factor, cellular response to dsRNA, positive regulation of canonical Wnt signaling pathway, positive regulation of hyaluronan biosynthetic process, cellular response to angiotensin, positive regulation of miRNA metabolic process. |
| BIOGRID_INTERACTION_ID | 110857 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205686 205687 205688 205689 205690 205691 |
| MONOCLONAL_ANTIBODY | Anti-NFkB p105 / p50 antibody for Human, Mouse, Rat |