Record No:1
| ACCESS NO | D109368 |
| GENE_NAME | MYC |
| DESCRIPTION | MYC proto-oncogene, bHLH transcription factor |
| ALIASES | MRTL, MYCC, bHLHe39, c-Myc. |
| NCBI_ENTREZ_NO | 4609 |
| UNIPROT_ACCESS_NO | P01106 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | MYC was increased in allergic rhinitis and asthmatic subjects as compared to healthy controls. MYC expression was significantly elevated in allergic rhinitis patients as compared to asthmatics. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), core promoter binding, DNA-binding transcription repressor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, mRNA binding, protein binding, transcription factor binding, activating transcription factor binding, protein-containing complex binding, protein dimerization activity, repressing transcription factor binding, E-box binding, eukaryotic initiation factor eIF2 binding. |
| GO_BIOLOGICAL_PROCESS | G1/S transition of mitotic cell cycle, negative regulation of transcription by RNA polymerase II, MAPK cascade, branching involved in ureteric bud morphogenesis, positive regulation of mesenchymal cell proliferation, energy reserve metabolic process, chromatin remodeling, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, cellular iron ion homeostasis, cellular response to DNA damage stimulus, cell cycle arrest, Notch signaling pathway, biological process, positive regulation of cell proliferation, response to gamma radiation, regulation of gene expression, positive regulation of gene expression, oxygen transport, protein deubiquitination, cytokine-mediated signaling pathway, regulation of telomere maintenance, negative regulation of stress-activated MAPK cascade, protein-DNA complex disassembly, cellular response to UV, cellular response to drug, response to drug, negative regulation of apoptotic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, fibroblast apoptotic process, negative regulation of monocyte differentiation, positive regulation of translation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of fibroblast proliferation, negative regulation of fibroblast proliferation, positive regulation of epithelial cell proliferation, chromosome organization, negative regulation of cell division, positive regulation of telomerase activity, ERK1 and ERK2 cascade, response to growth factor, cellular response to hypoxia, positive regulation of metanephric cap mesenchymal cell proliferation, regulation of somatic stem cell population maintenance, beta-catenin-TCF complex assembly, positive regulation of DNA methylation, positive regulation of DNA biosynthetic process, positive regulation of response to DNA damage stimulus. |
| BIOGRID_INTERACTION_ID | 110694 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204239 |
| MONOCLONAL_ANTIBODY | Anti-c-Myc antibody for Human, Mouse, Rat; Anti-c-Myc (phospho S62) antibody for Human, Rat, Mouse; Anti-c-Myc (phospho T58) antibody for Human. |