Record No:1
| ACCESS NO | D109385 |
| GENE_NAME | EGLN3 |
| DESCRIPTION | Egl-9 family hypoxia inducible factor 3 |
| ALIASES | HIFP4H3, HIFPH3, PHD3. |
| NCBI_ENTREZ_NO | 112399 |
| UNIPROT_ACCESS_NO | Q9H6Z9 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | EGLN3 was prominently increased in asthmatics as compared to allergic rhinitis patients and healthy controls. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Iron ion binding, protein binding, oxidoreductase activity, oxidoreductase activity (acting on paired donors, with incorporation or reduction of molecular oxygen), oxidoreductase activity (acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors), L-ascorbic acid binding, peptidyl-proline 4-dioxygenase activity, metal ion binding, dioxygenase activity. |
| GO_BIOLOGICAL_PROCESS | Response to hypoxia, apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, cellular response to DNA damage stimulus, protein hydroxylation, peptidyl-proline hydroxylation to 4-hydroxy-L-proline, regulation of cell proliferation, regulation of neuron apoptotic process, oxidation-reduction process, regulation of transcription from RNA polymerase II promoter in response to hypoxia. |
| BIOGRID_INTERACTION_ID | 125185 |
| SNP_ID | - |
| DRUG_ID | 4148 |
| STRUCTURE_ID | 207417 |
| MONOCLONAL_ANTIBODY | Anti-PHD3 antibody for Human, Mouse, Rat. |