Record No:1
| ACCESS NO | D109389 |
| GENE_NAME | CDKN1A |
| DESCRIPTION | Cyclin dependent kinase inhibitor 1A |
| ALIASES | CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1. |
| NCBI_ENTREZ_NO | 1026 |
| UNIPROT_ACCESS_NO | P38936 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | CDKN1A was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Protein kinase inhibitor activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, kinase activity, protein kinase binding, cyclin-dependent protein kinase activating kinase activity, cyclin binding, ubiquitin protein ligase binding, protein-containing complex binding, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Regulation of cyclin-dependent protein serine/threonine kinase activity, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, regulation of transcription by RNA polymerase II, transcription initiation from RNA polymerase II promoter, protein import into nucleus, cellular response to DNA damage stimulus, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cell cycle, cell cycle arrest, Ras protein signal transduction, regulation of mitotic cell cycle, heart development, negative regulation of cell proliferation, response to UV, response to toxic substance, response to organic substance, response to X-ray, response to organonitrogen compound, negative regulation of gene expression, positive regulation of cell death, response to organic cyclic compound, phosphorylation, cytokine-mediated signaling pathway, negative regulation of cell growth, positive regulation of B cell proliferation, animal organ regeneration, cellular response to extracellular stimulus, cellular response to amino acid starvation, cellular response to heat, tissue regeneration, negative regulation of phosphorylation, response to drug, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of apoptotic process, positive regulation of programmed cell death, negative regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of protein kinase activity, response to arsenic-containing substance, positive regulation of fibroblast proliferation, protein stabilization, response to glucocorticoid, response to corticosterone, regulation of cell cycle, response to hyperoxia, intestinal epithelial cell maturation, cellular response to ionizing radiation, cellular response to gamma radiation, cellular response to UV-B, mitotic cell cycle arrest, signal transduction by p53 class mediator, cellular senescence, replicative senescence, stress-induced premature senescence, intrinsic apoptotic signaling pathway, negative regulation of cyclin-dependent protein kinase activity, positive regulation of cyclin-dependent protein kinase activity, negative regulation of vascular smooth muscle cell proliferation, negative regulation of cardiac muscle tissue regeneration, negative regulation of G1/S transition of mitotic cell cycle, regulation of DNA biosynthetic process, positive regulation of reactive oxygen species metabolic process. |
| BIOGRID_INTERACTION_ID | 107460 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204184 204185 204186 |
| MONOCLONAL_ANTIBODY | Anti-p21 antibody for Mouse, Rat, Human, African green monkey. |