Record No:1
| ACCESS NO | D109404 |
| GENE_NAME | ATF3 |
| DESCRIPTION | Activating transcription factor 3 |
| ALIASES | - |
| NCBI_ENTREZ_NO | 467 |
| UNIPROT_ACCESS_NO | P18847 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | ATF3 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Transcription regulatory region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA-binding transcription repressor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, transcription corepressor activity, protein binding, identical protein binding, protein homodimerization activity, transcription regulatory region DNA binding, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, gluconeogenesis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, positive regulation of cell proliferation, positive regulation of gene expression, endoplasmic reticulum unfolded protein response, cellular response to amino acid starvation, skeletal muscle cell differentiation, PERK-mediated unfolded protein response, negative regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance, negative regulation of ERK1 and ERK2 cascade, positive regulation of TRAIL-activated apoptotic signaling pathway, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. |
| BIOGRID_INTERACTION_ID | 106957 |
| SNP_ID | 300424 300425 300426 300427 300428 300429 300430 |
| DRUG_ID | - |
| STRUCTURE_ID | 204497 |
| MONOCLONAL_ANTIBODY | Anti-ATF3 antibody for Human, Mouse, Rat. |