Record No:1
| ACCESS NO | D109407 |
| GENE_NAME | NR4A2 |
| DESCRIPTION | Nuclear receptor subfamily 4 group A member 2 |
| ALIASES | HZF-3, NOT, NURR1, RNR1, TINUR. |
| NCBI_ENTREZ_NO | 4929 |
| UNIPROT_ACCESS_NO | P43354 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | NR4A2 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, steroid hormone receptor activity, nuclear receptor activity, protein binding, beta-catenin binding, zinc ion binding, glucocorticoid receptor binding, protein homodimerization activity, sequence-specific DNA binding, metal ion binding, retinoid X receptor binding, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, response to hypoxia, neuron migration, response to amphetamine, DNA-templated transcription, regulation of DNA-templated transcription, transcription initiation from RNA polymerase II promoter, signal transduction, nervous system development, adult locomotory behavior, post-embryonic development, gene expression, regulation of gene expression, central nervous system projection neuron axonogenesis, central nervous system neuron differentiation, habenula development, neuron differentiation, intracellular receptor signaling pathway, cellular response to extracellular stimulus, cellular response to oxidative stress, regulation of dopamine metabolic process, dopamine biosynthetic process, dopamine metabolic process, neuron maturation, positive regulation of catalytic activity, steroid hormone mediated signaling pathway, negative regulation of neuron apoptotic process, regulation of respiratory gaseous exchange, fat cell differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, general adaptation syndrome, canonical Wnt signaling pathway, cellular response to corticotropin-releasing hormone stimulus, dopaminergic neuron differentiation, midbrain dopaminergic neuron differentiation, negative regulation of apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 110983 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204461 |
| MONOCLONAL_ANTIBODY | Anti-Nurr1 antibody for Human, Mouse, Rat. |