Record No:1
| ACCESS NO | D109408 |
| GENE_NAME | FOS |
| DESCRIPTION | FBJ murine osteosarcoma viral oncogene homolog |
| ALIASES | AP-1, C-FOS, p55. |
| NCBI_ENTREZ_NO | 2353 |
| UNIPROT_ACCESS_NO | P01100 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | FOS was significantly decreased in asthmatics as compared to healthy subjects and allergic rhinitis patients. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity (sequence-specific DNA binding), transcription factor activity (RNA polymerase II proximal promoter sequence-specific DNA binding), transcriptional activator activity (RNA polymerase II proximal promoter sequence-specific DNA binding), RNA polymerase II activating transcription factor binding, transcriptional activator activity (RNA polymerase II transcription factor binding), DNA binding, chromatin binding, double-stranded DNA binding, DNA binding transcription factor activity, protein binding, transcription factor binding, sequence-specific DNA binding, transcription regulatory region DNA binding, protein heterodimerization activity, R-SMAD binding. |
| GO_BIOLOGICAL_PROCESS | Conditioned taste aversion, DNA methylation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, inflammatory response, transforming growth factor beta receptor signaling pathway, nervous system development, female pregnancy, aging, response to cold, response to light stimulus, response to mechanical stimulus, response to gravity, response to toxic substance, response to organic cyclic compound, cytokine-mediated signaling pathway, sleep, cellular response to extracellular stimulus, response to lipopolysaccharide, response to progesterone, cellular response to hormone stimulus, response to cytokine, cellular response to reactive oxygen species, response to immobilization stress, skeletal muscle cell differentiation, response to muscle stretch, Fc-epsilon receptor signaling pathway, response to drug, positive regulation of osteoclast differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA binding transcription factor activity, response to corticosterone, response to cAMP, SMAD protein signal transduction, cellular response to cadmium ion, cellular response to calcium ion, positive regulation of neuron death, positive regulation of pri-miRNA transcription by RNA polymerase II. |
| BIOGRID_INTERACTION_ID | 108636 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200161 |
| MONOCLONAL_ANTIBODY | Anti-c-Fos antibody for Human, Monkey, Rat, Mouse; Anti-c-Fos (phospho S362) antibody for Human, Mouse, Rat. |