Record No:1
| ACCESS NO | D109430 |
| GENE_NAME | HBEGF |
| DESCRIPTION | Heparin-binding EGF-like growth factor |
| ALIASES | DTR, DTS, DTSF, HEGFL. |
| NCBI_ENTREZ_NO | 1839 |
| UNIPROT_ACCESS_NO | Q99075 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | HBEGF was significantly decreased in asthmatics as compared to allergic rhinitis patients and healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Protein tyrosine kinase activity, Ras guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, growth factor activity, heparin binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, signal transduction, epidermal growth factor receptor signaling pathway, muscle organ development, regulation of heart contraction, positive regulation of cell proliferation, regulation of signaling receptor activity, cell migration, peptidyl-tyrosine phosphorylation, positive regulation of cell growth, positive regulation of cell migration, wound healing, spreading of epidermal cells, ERBB2 signaling pathway, phosphatidylinositol phosphorylation, positive regulation of smooth muscle cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of elastin biosynthetic process, positive regulation of keratinocyte migration, positive regulation of protein kinase B signaling, cell chemotaxis, regulation of molecular function, positive regulation of wound healing, negative regulation of ERBB signaling pathway, regulation of cell motility. |
| BIOGRID_INTERACTION_ID | 108172 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200334 200335 |
| MONOCLONAL_ANTIBODY | Anti-HBEGF/DTR antibody for Human, Rat. |