Record No:1
| ACCESS NO | D109450 |
| GENE_NAME | DLL1 |
| DESCRIPTION | Delta like canonical Notch ligand 1 |
| ALIASES | DELTA1, DL1, Delta, NEDBAS. |
| NCBI_ENTREZ_NO | 28514 |
| UNIPROT_ACCESS_NO | O00548 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | DLL1 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Notch binding, calcium ion binding, protein binding, Tat protein binding, scaffold protein binding. |
| GO_BIOLOGICAL_PROCESS | Cell fate determination, somitogenesis, somite specification, heart looping, marginal zone B cell differentiation, type B pancreatic cell development, cell communication, Notch signaling pathway, cell-cell signaling, multicellular organism development, determination of left/right symmetry, compartment pattern specification, regulation of blood pressure, positive regulation of cell proliferation, negative regulation of cell proliferation, proximal/distal pattern formation, positive regulation of gene expression, astrocyte development, regulation of somitogenesis, spinal cord development, cerebellar molecular layer formation, cerebellar Purkinje cell layer structural organization, hemopoiesis, cell differentiation, regulation of cell adhesion, negative regulation of epithelial cell differentiation, negative regulation of interleukin-10 production, negative regulation of glial cell apoptotic process, organ growth, regulation of growth, negative regulation of cell differentiation, negative regulation of epidermal cell differentiation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of myeloid cell differentiation, negative regulation of myoblast differentiation, negative regulation of neuron differentiation, negative regulation of Notch signaling pathway, positive regulation of Notch signaling pathway, positive regulation of endocytosis, positive regulation of transcription by RNA polymerase II, lateral inhibition, skeletal muscle tissue growth, regulation of skeletal muscle tissue growth, positive regulation of skeletal muscle tissue growth, neuron fate specification, inner ear development, regulation of neurogenesis, regulation of cell division, retina development in camera-type eye, retina morphogenesis in camera-type eye, Notch signaling pathway involved in arterial endothelial cell fate commitment, left/right axis specification, nephron development, proximal tubule development, loop of Henle development, clathrin-dependent endocytosis, energy homeostasis, endothelial tip cell fate specification, neuronal stem cell population maintenance, skin epidermis development, regulation of vascular endothelial growth factor signaling pathway, positive regulation of sprouting angiogenesis, negative regulation of cardiac muscle cell differentiation. |
| BIOGRID_INTERACTION_ID | 118391 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207485 |
| MONOCLONAL_ANTIBODY | - |