Record No:1
ACCESS NO | D109451 |
GENE_NAME | PER1 |
DESCRIPTION | Period circadian regulator 1 |
ALIASES | PER, RIGUI, hPER. |
NCBI_ENTREZ_NO | 5187 |
UNIPROT_ACCESS_NO | O15534 |
ORGANISM | Human |
DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
SAMPLE | CD4 T cells |
TECHNIQUES | RNA Sequencing |
OMICS | Transcriptomics |
STUDY | High Throughput |
GEO_PRIDE_ACCESS_NO | GSE75011 |
COMMENTS | PER1 was significantly decreased in asthmatics as compared to allergic rhinitis patients and healthy subjects. |
REFERENCE | 27271570 |
IMMUNITY_TERM | No |
GO_MOLECULAR_FUNCTION | Transcription regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, transcription factor activity ( transcription factor binding), transcription corepressor binding, protein binding, transcription factor binding, kinase binding, chromatin DNA binding, ubiquitin protein ligase binding, E-box binding. |
GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, regulation of sodium ion transport, DNA-templated transcription, regulation of DNA-templated transcription, circadian rhythm, response to light stimulus, entrainment of circadian clock, posttranscriptional regulation of gene expression, circadian regulation of gene expression, regulation of hair cycle, regulation of circadian rhythm, negative regulation of I-kappaB kinase/NF-kappaB signaling, entrainment of circadian clock by photoperiod, histone H3 acetylation, histone H4 acetylation, negative regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of JNK cascade, rhythmic process, response to cAMP, histone H3 deacetylation, circadian regulation of translation, regulation of cytokine production involved in inflammatory response, regulation of p38MAPK cascade, negative regulation of glucocorticoid receptor signaling pathway. |
BIOGRID_INTERACTION_ID | 111210 |
SNP_ID | - |
DRUG_ID | - |
STRUCTURE_ID | 200888 |
MONOCLONAL_ANTIBODY | - |