Record No:1
| ACCESS NO | D109469 |
| GENE_NAME | GADD45A |
| DESCRIPTION | Growth arrest and DNA damage inducible alpha |
| ALIASES | DDIT1, GADD45. |
| NCBI_ENTREZ_NO | 1647 |
| UNIPROT_ACCESS_NO | P24522 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | GADD45A was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II core promoter sequence-specific DNA binding, protein binding, kinase binding, protein homodimerization activity, protein heterodimerization activity, protein N-terminus binding. |
| GO_BIOLOGICAL_PROCESS | Regulation of cyclin-dependent protein serine/threonine kinase activity, activation of MAPKKK activity, DNA repair, negative regulation of protein kinase activity, apoptotic process, cellular response to DNA damage stimulus, DNA damage response (signal transduction by p53 class mediator resulting in cell cycle arrest), cell cycle, cell cycle arrest, centrosome cycle, signal transduction in response to DNA damage, positive regulation of apoptotic process, positive regulation of JNK cascade, regulation of cell cycle, cellular response to mechanical stimulus, cellular response to ionizing radiation, mitotic cell cycle arrest, positive regulation of p38MAPK cascade, positive regulation of reactive oxygen species metabolic process. |
| BIOGRID_INTERACTION_ID | 108014 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204208 |
| MONOCLONAL_ANTIBODY | - |