Record No:1
| ACCESS NO | D109492 |
| GENE_NAME | NFKBIA |
| DESCRIPTION | NFKB inhibitor alpha |
| ALIASES | EDAID2, IKBA, MAD-3, NFKBI. |
| NCBI_ENTREZ_NO | 4792 |
| UNIPROT_ACCESS_NO | P25963 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | NFKBIA was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protein binding, transcription factor binding, nuclear localization sequence binding, enzyme binding, ubiquitin protein ligase binding, identical protein binding, NF-kappaB binding. |
| GO_BIOLOGICAL_PROCESS | Protein import into nucleus, apoptotic process, I-kappaB kinase/NF-kappaB signaling, cytoplasmic sequestering of NF-kappaB, regulation of gene expression, negative regulation of macrophage derived foam cell differentiation, positive regulation of cholesterol efflux, negative regulation of lipid storage, viral process, protein deubiquitination, lipopolysaccharide-mediated signaling pathway, negative regulation of NF-kappaB transcription factor activity, positive regulation of cellular protein metabolic process, response to muramyl dipeptide, response to lipopolysaccharide, tumor necrosis factor-mediated signaling pathway, toll-like receptor 4 signaling pathway, response to muscle stretch, regulation of cell proliferation, cytoplasmic sequestering of transcription factor, negative regulation of apoptotic process, response to exogenous dsRNA, negative regulation of DNA binding, negative regulation of myeloid cell differentiation, negative regulation of Notch signaling pathway, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of inflammatory response, cellular response to cold, nucleotide-binding oligomerization domain containing 1 signaling pathway, nucleotide-binding oligomerization domain containing 2 signaling pathway, interleukin-1-mediated signaling pathway, cellular response to tumor necrosis factor, regulation of NIK/NF-kappaB signaling. |
| BIOGRID_INTERACTION_ID | 110859 |
| SNP_ID | - |
| DRUG_ID | 4141 |
| STRUCTURE_ID | 204748 |
| MONOCLONAL_ANTIBODY | Anti-IKB alpha antibody for Human, Mouse, Rat, Hamster, African green monkey; Anti-IKB alpha (phospho S36) antibody for Human, Mouse; Anti-IKB alpha (phospho S32) antibody for Human; Anti-IKB alpha (phospho Y42) antibody for Human. |