Record No:1
| ACCESS NO | D109497 |
| GENE_NAME | SESN2 |
| DESCRIPTION | Sestrin 2 |
| ALIASES | HI95, SES2, SEST2. |
| NCBI_ENTREZ_NO | 83667 |
| UNIPROT_ACCESS_NO | P58004 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | SESN2 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | GDP-dissociation inhibitor activity, protein binding, oxidoreductase activity, oxidoreductase activity acting on peroxide as acceptor, NOTÂ sulfiredoxin activity, leucine binding. |
| GO_BIOLOGICAL_PROCESS | Regulation of protein phosphorylation, regulation of gluconeogenesis, fatty acid beta-oxidation, mitochondrion organization, response to glucose, positive regulation of macroautophagy, negative regulation of cell growth, DNA damage response (signal transduction by p53 class mediator), mitochondrial DNA metabolic process, response to insulin, cellular response to amino acid starvation, cellular response to oxidative stress, positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress, cellular response to glucose starvation, glucose homeostasis, protein kinase B signaling, glucose import, oxidation-reduction process, triglyceride homeostasis, cellular response to amino acid stimulus, cellular response to leucine, reactive oxygen species metabolic process, cellular oxidant detoxification, positive regulation of protein localization to nucleus, regulation of response to reactive oxygen species, negative regulation of translation in response to endoplasmic reticulum stress, negative regulation of TORC1 signaling, positive regulation of lipophagy, cellular response to leucine starvation, regulation of cAMP-dependent protein kinase activity. |
| BIOGRID_INTERACTION_ID | 123724 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207518 207519 207520 207521 |
| MONOCLONAL_ANTIBODY | Anti-SESN2/Sestrin-2 antibody for Human, Mouse, Rat. |