Record No:1
| ACCESS NO | D109506 |
| GENE_NAME | MAPK7 |
| DESCRIPTION | Mitogen-activated protein kinase 7 |
| ALIASES | BMK1, ERK4, ERK5, PRKM7. |
| NCBI_ENTREZ_NO | 5598 |
| UNIPROT_ACCESS_NO | Q13164 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | MAPK7 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, MAP kinase activity, protein binding, ATP binding, kinase activity, transferase activity, mitogen-activated protein kinase binding. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, protein phosphorylation, cell cycle, signal transduction, axon guidance, regulation of gene expression, phosphorylation, peptidyl-serine phosphorylation, cAMP-mediated signaling, cell differentiation, negative regulation of heterotypic cell-cell adhesion, intracellular signal transduction, positive regulation of transcription from RNA polymerase II promoter in response to stress, negative regulation of apoptotic process, regulation of angiogenesis, positive regulation of transcription by RNA polymerase II, negative regulation of inflammatory response, positive regulation of protein metabolic process, negative regulation of cyclic-nucleotide phosphodiesterase activity, negative regulation of response to cytokine stimulus, cellular response to hydrogen peroxide, negative regulation of calcineurin-NFAT signaling cascade, cellular response to growth factor stimulus, cellular response to laminar fluid shear stress, cellular response to transforming growth factor beta stimulus, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. |
| BIOGRID_INTERACTION_ID | 111584 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207529 207530 |
| MONOCLONAL_ANTIBODY | Anti-ERK5 antibody for Human, Mouse, Rat. |