Record No:1
| ACCESS NO | D109511 |
| GENE_NAME | UHRF1 |
| DESCRIPTION | Ubiquitin like with PHD and ring finger domains 1 |
| ALIASES | ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95. |
| NCBI_ENTREZ_NO | 29128 |
| UNIPROT_ACCESS_NO | Q96T88 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | UHRF1 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Proximal promoter sequence-specific DNA binding, DNA binding, ubiquitin-protein transferase activity, protein binding, zinc ion binding, methyl-CpG binding, transferase activity, nucleosomal histone binding, methylated histone binding, histone binding, identical protein binding, hemi-methylated DNA-binding, metal ion binding, ubiquitin protein ligase activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, DNA repair, chromatin organization, ubiquitin-dependent protein catabolic process, cellular response to DNA damage stimulus, cell cycle, maintenance of DNA methylation, histone monoubiquitination, protein ubiquitination, histone ubiquitination, positive regulation of cellular protein metabolic process, positive regulation of transcription by RNA polymerase II, regulation of epithelial cell proliferation, protein autoubiquitination, positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity. |
| BIOGRID_INTERACTION_ID | 118893 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207532 207533 207534 207535 207536 207537 207538 207539 207540 207541 207542 |
| MONOCLONAL_ANTIBODY | Anti-UHRF1 antibody for Human, Rat, Mouse. |